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基本信息:

姓名: 夏宏光
职务: Principle investigator
职称: 研究员
学历: 博士
专业: 生物化学
所属院系: 基础医学系
研究方向: 利用化学生物学研究细胞自噬、细胞死亡和神经炎症的分子生物学机制,同时研究神经退行性疾病、肿瘤、衰老等疾病的发病机制并开发对应的靶向药物。
电话: 0571-88981119
信箱: hongguangxia@zju.edu.cn
个人主页: http://person.zju.edu.cn/xlab

个人简介:

个人简介:
2011年毕业于中科院上海有机化学研究所获博士学位,2011-2012年任中科院上海有机化学研究所助理研究员,2012-2015年在哈佛大学医学院从事博士后研究工作。2015年全职回国,受聘浙江大学医学院生化系“百人计划”研究,博士生导师。
已发表20多篇SCI论文,近五年来共发表SCI论文14篇,其中以第一作者、共同第一作者和共同通讯作者在Cell、Journal of Cell Biology、Journal of Clinical Investigation、Autophagy和Chemical Communications等领域内顶尖杂志发表论文8篇,取得了一系列有重要影响和价值的创新性成果。获得两项国际专利,作为主要发明人之一发明的第四代EGFR有机小分子抑制剂已经进入IND(新药临床前研究)阶段;作为主要发明人之一发明的自噬有机小分子抑制剂Spautin1已经被多家国际试剂公司商业化并广泛应用于基础科学研究和临床研究领域。
 
代表论文:
1.Yuanyuan An, Hongguang Xia* and Jie Wu*. A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines. Organic & Biomolecular Chemistry Accepted. (IF: 3.6)
2. Xiaolin Pan, Yong Luo, Hong-guang Xia* and Jie Wu*. A palladium-catalyzed tandem reaction of 2-(2-bromobenzylidene)cyclobutanone with 2-alkynylphenol. Chemical Communications Accpeted. (IF: 6.8)
3. Xiaolin Pan, He Wang, Hong-guang Xia* and Jie Wu*. An unexpected three-component reaction of 2-alkylenecyclobutanone, N'-(2-alkynylbenzylidene)hydrazide with water. RSC Advances Accepted. (IF: 3.8)
4. Lorena Galan-Acosta#, Hongguang Xia#, Junying Yuan and Helin Vakifahmetoglu-Norberg. Activation of Chaperone-Mediated Autophagy as a potential anticancer therapy. Autophagy Accepted. (IF: 11.4)
#Co-first authors.
5. Hong-guang Xia, Ayaz Najafov, Jiefei Geng, Xuemei Han, Lorena Galan-Acosta, Bing Shan, Yaoyang Zhang, Erik Norberg, Tao Zhang, Lifeng Pan, Junli Liu, Jonathan L. Coloff, Dimitry Ofengeim, Hong Zhu, Kejia Wu, Yu Cai, John R. Yates, Junying Yuan* and Helin Vakifahmetoglu-Norberg. Degradation of HK2 by Chaperone-Mediated Autophagy promotes Metabolic Catastrophe and Cell Death. J. Cell Biol. 2015 August; 210(5): 705-716. (IF: 9.7)
6. Tao Zhang, Kangyun Dong$, Wei Liang$, Daichao Xu$, Hongguang Xia$, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu, Junying Yuan*. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. E-life. 2015 March. (IF: 8.5)
$Co-second authors
7. Helin Vakifahmetoglu-Norberg#, Hong-guang Xia#, Junying Yuan*. Pharmacologic agents targeting autophagy. J. Clin. Invest. 2015 Jan; 125(1): 5-13. (IF: 13.8)
#Co-first authors.
8. Helin V. N., Minsu K., Hong-guang Xia, Marcin P. Iwanicki, Dimitry Ofengeim, Jonathan L. Coloff, Lifeng P., Tan A. Ince, Guido Kroemer, Joan S. Brugge and Junying Yuan. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Aug; 27(15): 1718-1730. (IF: 12.6)
9. Junli Liu#, Hong-guang Xia#, Lihong Zhang, Lihua Xu, Ying Li, Cai Yu, Minsu Kim, Tao Zhang, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Dawei Ma, and Junying Yuan. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13. Cell 2011 Sep; 147(1): 223-234. (IF: 33.1)
#Co-first authors.
10. Xiuquan Ma, Mingzhi Jin, Yu Cai, Hong-guang Xia, Kai Long, Junli Liu, Qiang Yu and Junying Yuan. Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy. (IF: 6.2) Chemistry & Biology 2011 Nov; 18(11): 1474-1481.
11. Gang Chen, Hong-guang Xia, Yu Cai, Dawei Ma, Junying Yuan and Chengye Yuan. Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies. Med Chem Comm 2011 Feb; 2: 315-320. (IF: 2.5)
12. Gang Chen, Hong-guang Xia, Yu Cai, Dawei Ma, Junying Yuan and Chengye Yuan. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.Bioorganic & Medicinal Chemistry Letters 2011 Jan; 21(1): 234-239. (IF: 2.3)
13. Wenhua Li, Shouyun Yu, Mingzhi Jin, Hong-guang Xia, Dawei Ma. Total synthesis and cytotoxicity of bisebromoamide and its analogues. Tetrahedron Letters 2011 April; 52(17): 2124–2127. (IF: 2.4)
14. Hong-guang Xia, Lihong Zhang, Gang Chen, Tao Zhang, Junli Liu, Mingzhi Jin, Xiuquan Ma, Dawei Ma, and Junying Yuan. Control of basal autophagy by calpain1 mediated cleavage of ATG5 . Autophagy 2010 Jan; 6(1): 61-66. (IF: 11.4)