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基本信息:

姓名: 单鹏飞
职务: 浙医二院教学部副主任
职称: 主任医师
学历: 博士
专业: 内分泌代谢病学
所属院系: 浙医二院
研究方向: 糖尿病 代谢综合征 钙磷代谢
电话: 87784623
信箱: pengfeishan@zju.edu.cn
个人主页:

个人简介:

博士,浙江大学医学院附属第二医院主任医师,博士研究生导师。毕业于湘雅医学院,分别获学士、硕士和博士学位,哈佛大学医学院Joslin糖尿病中心留学专家。浙江省医学会内分泌学分会中青年副主任委员,中华医学会骨质疏松和骨矿盐疾病分会社区与基层工作学组委员,浙江省医学会营养学分会慢病管理学组委员,省医师协会专家志愿者,SCI杂志International Journal of Endocrinology的Lead Guest Editor,SCI杂志审稿专家,国家自然科学基金一审专家,中华内分泌代谢杂志特邀审稿专家。主持国家自然科学基金4项。擅长糖尿病、肥胖、代谢综合征、骨质疏松、垂体、甲状腺疾病等内分泌疾病的临床诊治。致力于糖尿病、代谢综合征综合治疗和逆转2型糖尿病和代谢综合征的研究。

近年的主要研究项目

 

1. 国家自然科学基金面上项目:项目编号81870564OPG/RANKL/RANK系统调控血管新生改善糖尿病小鼠下肢股动脉缺血损伤及机制研究, 2019/01-2022/12,直接经费57万元,主持。

2. 国家自然科学基金面上项目,81670744,血浆激肽释放酶酶切NMDA受体1促进糖尿病视网膜神经损伤及其机制研究,2017/01-2020/12,总经费69.6万,主持。

3. 国家自然科学基金面上项目,81370968,Apelin/APJ 系统调控动脉钙化的模式和机制研究,2014/01-2017/12,80万,主持。

4. 国家自然科学基金面上项目,Annexin A2糖基化在高血糖加重缺血性脑损伤中的作 用及机制研究,2011 /01-2014/12,67万,参加。

5. 国家自然科学基金项目,30801203, 护骨素调控血管平滑肌细胞向成骨细胞分化 对动脉钙化的影响及机理研究,2009/01-2011/12,20万,主持。

6. 浙江省卫生厅优秀人才基金,2009QN012,核因子-κB活化因子配体抑制剂(Denos umab)干预LDLR(-/-)小鼠动脉钙化和动脉粥样硬化的研究;2009/6-2011/6,3万,主持。



参编的主要著作:

译著《全科医学临床住院医师指导手册》,2017,人民卫生出版社, Mori J. Morikawa主编;

《临床甲状腺病学》,2013,人民卫生出版社,向光大主编;

《内分泌学》第3版,2012,人民卫生出版社,廖二元主编;

《内分泌学》第2版,2007,人民卫生出版社,廖二元主编;

《内分泌学手册》,2006,人民卫生出版社,廖二元主编;

《代谢性骨病学》,2003,人民卫生出版社,廖二元主编;

《激素敏感综合征和激素不敏感综合征》,2002,人民卫生出版社,廖二元主编)。

发表的主要学术论文:

1. Wu Y, He J, Sun X, Zhao YM, Lou HY, Ji XL, Pang XH, Shan LZ, Kang YX, Xu J, Zhang SZ, Wang YJ, Ren YZ, Shan PF*. Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus, Medicine (Baltimore), 2017, 96(39):e8151.(通讯作者)

2. Pang XH, Han J, Ye WL, Sun X, Ding Y, Huang WJ, Zhao YM, Lou HY, Shan LZ, Kang YX, Song XX, Zhang SZ, Gu W, Shan PF*. Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China. Int J Endocrinol, 2017, 2017:9620513. (通讯作者)

3. Shan PF*, Li Q, Khamaisi M, Qiang GF. Type 2 Diabetes Mellitus and Macrovascular Complications. Int J Endocrinol, 2017;2017:4301461. (通讯作者)

4. Ding Y, Sun X, Shan PF. MicroRNAs and Cardiovascular Disease in Diabetes Mellitus. Biomed Res Int. 2017;2017:4080364. (通讯作者)

5. Sun X, He J, Ji XL, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zeng WH, Pang XH, Zhang SZ, Ding Y, Ren YZ, Shan PF*. Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Paents with Type 2 Diabetes Mellitus: An Observational Cross-sectional Study in Hangzhou, China. Chin Med J (Engl). 2017 5th Jan 2017;130(1):57-63. (通讯作者)

6. Sun X, Shan PF, Ding Y, Yu H, Song ZY. Comment on Gagnum et al. Long-term Mortality and End-Stage Renal Disease in a Type 1 Diabetes Population Diagnosed at Age 15-29 Years in Norway. Diabetes Care 2017;40:38-45. Diabetes Care. 2017 Sep;40(9):e124.

7. Yao MF, He J, Sun X, Ji XL, Ding Y, Zhao YM, Lou HY, Song XX, Shan LZ, Kang YX, Zhang SZ, Shan PF*. Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China. Int J Endocrinol. 2016;2016:8483405. (通讯作者)

8. Shan PF, Ji XL, Wang L, Li P, Ren YZ. Comment on Tang et al. Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial. Diabetes Care 2015;38:1339-1346. Diabetes Care. 2015 Sep;38(9):e148–9.

9. Yuan LQ, Ouyang HW, Andersen TL, Jiang Y, Pantano F, Shan PF. Osteoporosis 2014. Int J Endocrinol. 2015; 2015:567593.

10. Shan PF, Ji XL. Comment on Lin et al. Risk Factors for Decline in IQ in Youth With Type 1 Diabetes Over the 12 Years From Diagnosis/Illness Onset. Diabetes Care 2015;38:236-242. Diabetes Care. 2015 Aug;38(8):e120.

11. Zou QL, Wei GN, Chen JX, Ye Q,  Shan PF*.Hepatitis B virus-associated nephropathy in a patient with diabetes mellitus. J Diabetes Investig 2014;5(1):87–89. (通讯作者)

12. Zheng J, Shan PF, Gu W. The efficacy of metformin in pregnant women with polycystic ovary syndrome: a meta-analysis of clinical trials. J Endocrinol Invest 2013;36(10):797802.(共同第一作者)

13. Zhu X, Jiang Y, Shan PF, Shen J, Liang QH, Cui RR, Liu Y, Liu GY, Wu SS, Lu Q, Xie H, Liu YS, Yuan LQ, Liao EY. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids, 44(3):961–968, 2013.

14. Shan PF, Xian CJ, Li M, Xiang GD, Yuan LQ. Osteoporosis. Int J Endocrinol. 2013;2013:952858.

15. Yin JH, Song ZY, Shan PF*, Xu J, Ye ZM, Xu XH, Zhang SZ, Liang Q, Zhao Y, Ren Z, Yu YP. Age- and gender-specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China. Clin Endocrinol (Oxf), 76(6):802–809, 2012

(通讯作者)

16. Shan PF, Lu Y, Cui RR, Jiang Y, Yuan LQ, Liao EY. Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. PLoS One 2011, 6(3):e17938.

17. Shan PF, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Age-related bone mineral density, osteoporosis rate and risk of vertebral fracture in mainland Chinese women with type 2 diabetes mellitus. J Endocrinol Invest. 2011 Mar;34(3):190–196.

18. Shan PF, Wu XP, Zhang H, Cao XZ, Gu W, Deng XG, Gu C, Liao EY. Bone mineral density and its relationship with Body mass index in postmenopausal women with type 2 diabetes mellitus in mainland China. J Bone Miner Metab 2009, 27:190–197.

19. Shan PF, Wu XP, Zhang H, Luo XH, Cao XZ, Xie H, Liu SP, Pi YZ, Fang TY, Liu H, Chen ZH, Zhong N, Liao EY. Age-related changes of serum bone alkaline phosphatase and cross-linked c-telopeptides of type I collagen and the relationship with bone mineral density in Chinese women. Clin Chim Acta, 2006, 366, 233–238.

20. Gu W, Zou LX, Shan PF, Chen YD. Analysis of urinary proteomic patterns for diabetic nephropathy by ProteinChip. Protemics Clinical Applications 2008; 2: 744–750.

21. Wu XP, Hou YL, Zhang H, Shan PF, Zhao Q, Cao XZ, Dai RC, Luo XH, Liao EY.

Establishment of BMD reference databases for the diagnosis and evaluation of osteoporosis in central southern Chinese men. J Bone Miner Metab. 2008;26(6):586-94.

22. Tang SY, Shan PF, Xie H, Wu XP, Liao EY, Zhang H. Bone mineral content and bone mineral density at lumbar spine and forearm in Chinese girls aged 6-18 years. J Endocrinol Invest, 2007, 30(3): 205–209.

23. Luo XH, Guo LJ, Shan PF, Xie H, Wu XP, Zhang H, Cao XZ, Yuan LQ, Liao EY. Relationship of circulating MMP–2, MMP–1, and TIMP–1 levels with bone biochemical markers and bone mineral density in postmenopausal Chinese women. Osteoporos Int, 2006, 17: 521–526.

24. Wu XP, Dai RC, Shan PF, Yuan LQ, Cao XZ, Liao EY, Jiang Y. Establishment of BMD reference curves at different skeletal sites in women, using a Cartesian coordinate numeration system. Osteoporos Int, 2005, 16:1655–1662.

25. Guo LJ, Luo XH, Wu XP, Shan PF, Zhang H, Cao XZ, Xie H, Liao EY. Serum concentrations of MMP-1, MMP-2, and TIMP-1 in Chinese women: Age-related changes, and the relationships with bone biochemical markers, bone mineral density. Clin Chim Acta, 2006, 371: 137–142.

26. Wu XP, Liao EY, Dai RC, Shan PF, Fang TY, Luo XH, Pi YZ, Jiang Y. Comparison of spine and femur reference data in native Chinese women from different regions of China. Osteoporos Int, 2005, 16:1215–1224.

27. Wu XP, Liao EY, Zhang H, Shan PF, Cao XZ, Liu SP. Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis. Osteoporos Int, 2004, 15:71–79.

28. Wu XP, Liao EY, Zhang H, Dai RC, Shan PFCao XZ, Liu SP, Jiang Y. Relationship of body surface area with bone density and its risk of osteoporosis at various skeletal regions in women of mainland China. Osteoporos Int, 2004, 15:751–759.

29. Wu XP, Liao EY, Zhang H, Dai RC, Shan PF, Cao XZ, Liu SP, Jiang Y. Determination of age-specific bone mineral density and comparison of diagnosis and prevalence of primary osteoporosis in Chinese women based on both Chinese and World Health Organization criteria. J Bone Miner Metab, 2004, 22:382–391.

30. Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta, 2005, 351:161–168.

31. 姚美芳 ,孙雪,韩珏,屠伊娜,何洁,赵一鸣,楼寒钰,庞晓虹,曾文衡,张松照,单鹏飞,2型糖尿病患者合并代谢综合征增加Framingham心血管评分,浙江大学学报(医学版),2016.5.845(3)268~274

32.单鹏飞,继发于艾滋病的原发性肾上腺皮质功能减退一例,中华内科杂志,2012 516):481-482

33. 单鹏飞, 谷卫. 肥胖相关性肾损害及其临床处理. 实用糖尿病杂, 2007, 3:3–4.

34. 单鹏飞, 伍贤平, 张红, 罗湘杭, 曹行之, 谢辉, 刘石平, 廖二元. 女性护骨素启动子区209245多态性和骨密度及骨转换的关系. 中华内分泌代谢杂志, 2007, 23:228–230.

35. 单鹏飞, 伍贤平, 廖二元, 张红, 罗湘杭, 曹行之, 谢辉, 刘石平. 女性骨代谢转换生化指标和骨密度随年龄变化及其相互关系. 中华老年医学杂志, 2005, 24:431–434.

36. 单鹏飞, 伍贤平, 廖二元, 张红, 罗湘杭, 曹行之, 谢辉, 刘石平女性甲状旁腺激素随年龄变化规律及其与骨密度的关系.中华内科杂志, 2005, 443:213–214.

37. 张红, 单鹏飞, 罗湘杭, 伍贤平, 廖二元. 长沙市郊区女性骨质疏松纵向观察.中华医学杂志2006,86: 2986–2989.

38. 刘石平, 廖二元, 伍贤平, 曹行之, 单鹏飞, 苏欣. 尿Ⅰ型胶原羧基末端肽和氨基末端肽排泄率与年龄、绝经和绝经后骨丢失的关系. 中华医学杂志,2006,86: 371–375.

  39. 张红, 罗湘杭, 谢辉, 伍贤平, 单鹏飞, 曹行之, 廖二元. 基质金属蛋白酶-1-2与年龄、骨转换生化指标及骨密度的关系. 中华内科杂志, 2006, 45:306–309.