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基本信息:

姓名: 王福俤
职务: 公共卫生学院院长
职称: 教授
学历: 博士
专业: 营养学、生理学
所属院系: 公共卫生系
研究方向: 营养代谢;微量元素稳态代谢
电话: 0571-88208028
信箱: fwang@zju.edu.cn
个人主页: http://www.cmm.zju.edu.cn/chinese/scholar.php?uid=726

个人简介:

国家杰出青年基金获得者, 中国科学院百人计划学者,浙江大学公共卫生学院院长、浙江大学营养与食品安全研究所所长、浙江省海外高层次千人计划学者、求是特聘教授、营养学博士、博士生导师。
1992年获河北医科大学公共卫生学院学士学位,1995年获上海同济大学医学院营养与食品卫生学硕士学位,1998年第二军医大学军事预防医学博士学位。1998-2002年在第二军医大学海军医学系工作,先后任讲师、副教授、硕士生导师、教研室主任。2002-2004年在美国密苏理哥伦比亚大学营养系和生物化学系从事博士后研究。之后在美国哈佛大学医学院和波士顿儿童医院任研究员(Instructor);美国佛罗里达大学人类营养与食品系任研究副教授。2009年在中国科学院上海生命科学研究院营养科学研究所研究员、博士生导师、微量元素分子营养学研究组主任。2013年调任浙江大学公共卫生学院,任院长。现任国家卫生部食品安全国家标准评审委员会委员、中国营养学会老年营养分委会委员、上海营养学会理事、上海营养学会副主任委员、上海预防医学会营养与食品安全分委会委员、美国佛罗里达大学食品与人类营养系Courtesy Professor。目前承担国家自然科学基金项目杰出青年项目、重点项目(2项)、面上项目,国家重点基础研究发展计划(973计划)项目、科技部支撑计划及上海市基础研究重点项目等。在Nature Genetics、Nature、Blood、Hepatology等国际著名杂志发表论文80余篇,五年内论文他引近600余次;主编专著3部;申请专利7项;多次受邀在国内外做大会学术报告。

研究领域
运用涵盖分子生物学、细胞生物学、生物化学及遗传学等多学科前沿实验技术,以基因敲除小鼠、斑马鱼及人群流行病学为实验手段研究微量元素(主要是铁和锌)代谢的分子及遗传机制。主要研究方向如下:
1) 微量元素稳态代谢的分子和遗传机制,以及在疾病发生发展中的作用。矿物质和微量元素是构成人体组织和维持正常生理活动的重要物质,过少会引发相应的缺乏病,例如锌缺乏可引起小儿厌食、生长发育停滞以及免疫力降低等;铁缺乏可以引发缺铁性贫血。但这些矿物质和微量元素过量同样对健康造成极大危害。因此维持机体矿物质和微量元素平衡对人类健康至关重要。近年来由于分子生物学技术的发展,多种参与离子转运与代谢的新基因被克隆和鉴定,使人类对离子稳态调控分子机理有了一定的了解,但还有很多问题有待深入研究。
2)食品安全中的重金属危害分子机制及防治新措施研究。近年我国重金属污染事件频发,严重威胁国民健康与社会和谐。鉴于科学前沿及国家重大需求,食品安全中的重金属危害研究也成为我们的主要攻关方向:(1)重金属代谢分子机制研究;(2)重金属危害的人群流行病学研究;(3)以金属为靶点的生物活性单体筛选与机制研究。
3)新型功能食品的研发。以我国居民迅猛高发的重大代谢性疾病如糖尿病、代谢综合征、心血管疾病等为攻关核心,通过应用多种高新技术与现代营养学新理论,筛选天然食物或植物提取物功能因子,研发新型高效安全功能食品。该研究方向得到科技部支撑计划项目支持,申报国家专利7项。
4)公益健康科普宣教。致力于营养健康知识大众科普宣教,荣获上海市科学技术委员会授予的“上海科普宣讲大使”称号;创建 “西湖营养”微信公众宣教平台和微博,每天推送营养学新发现、新知识、新理论。请大家加“关注”!

联系电话:0571-88208028
E-mail: fwang@zju.edu.cn; fudiwang.lab@gmail.com
Website: www.phs.zju.edu.cn; www.wnutrition.org

Select Publications (From over 80 publications; * Corresponding author)
1. Mu M, Wu A, An P, Du X, Wu Q, Shen X, Wang F*. Black soybean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin. British Journal of Nutrition. Jan 2013, doi:10.1017/S0007114513004005. Epub 2014 Jan 6
2. Zhang Z, Guo X, Herrera C, Tao Y, Wu Q, Wu Q, Wang H, Bartnikas TB, Wang F*. Bmp6 expression can be regulated independently of liver iron in mice. PLoS ONE 10.1371/journal.pone.0084906 (Accepted)
3. Guan Y#, An P#, Zhang Z, Zhang F, Yu Y, Wu Q, Shi Y, Guo X, Tao Y, Wang F*. Screening identifies the Chinese medicinal plant Caulis Spatholobi as an effective HAMP expression inhibitor. Journal of Nutrition, 2013 Jul;143(7):1061-6. doi: 10.3945/jn.113.174201. Epub 2013 May 22.
4. Guo X, Zhang Z, Zhang F, Tao Y, An P, Wu Q, Wang C, Knutson MD, and Wang F*. Fine-mapping and genetic analysis of the loci affecting hepatic iron overload in mice. PLoS ONE. 2013 May 10;8(5):e63280. Print 2013.
5. Guo X#, Zhou DZ#, An P#, Wu Q, Wang H, Wu A, Mu M, Zhang D, Zhang Z, Wang H, He L, Liu Y*, Wang F*. Associations between serum hepcidin, ferritin, hemoglobin, and type 2 diabetes risks in a Chinese Han population. British Journal of Nutrition. 2013 Dec;110(12):2180-5. doi: 10.1017/S0007114513001827. Epub 2013 Jun 7
6. Yu Y#, Wu A#, Zhang Z, Yan G, Zhang F, Zhang L, Shen X, Hu R, Zhang Y*, Zhang K*, Wang F*. Characterization of the GufA Subfamily Member SLC39A11/Zip11 as a Zinc Transporter. Journal of Nutritional Biochemistry. 2013 Oct;24(10):1697-708. doi: 10.1016/j.jnutbio.2013.02.010. Epub 2013 May 2
7. Zhang Z, Zhang F, Guo X, An P, Tao Y, Wang F*. Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores. Hepatology. 2012 Sep;56(3):961-71
8. Jeong J, Walker J , Wang F, J. Park G, Palmer A, Giunta C, Rohrbach M, Steinmann B, Eide DJ. Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos Syndrome. Proc Natl Acad Sci USA. 2012 Dec 18;109(51):E3530-8
9. Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ and Wang F*. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood. 2011 Aug 18;118(7):1912-22
10. An P, Wu Q, Wang H, Guan Y, Mu M, Liao Y, Zhou D, Song P, Wang C, Meng L, Man Q, Li L, Zhang J, Wang F*. TMPRSS6, but not TF, TFR2, or BMP2 Variants are Associated with Increased Risk of Iron Deficiency Anemia. Human Molecular Genetics. 2012 May 1;21(9):2124-31
11. Zhang F, Tao Y, Zhang Z, Guo X, An P, Shen Y, Wu Q, Yu Y, Wang F*. Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses. Haematologica. 2012 Dec;97(12):1826-35
12. Gan W, Guan Y, Wu Q, An P, Zhu J, Lu L, Jing L, Yu Y, Ruan S, Xie D, Makrides M, Gibson RA, Anderson GJ, Li H*, Lin X* and Wang F*. Association of TMPRSS6 polymorphisms with ferritin, hemoglobin and type 2 diabetes risk in a Chinese Han population. The American Journal of Clinical Nutrition. 2012 Mar;95(3):626-32
13. Yan G, Zhang Y, Yu J, Yu Y, Zhang F, Zhang Z, Wu A, Yan X, Zhou Y, Wang F*. Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS ONE. 2012;7(8):e42939
14. Sun L#, Yu Y#, Huang T#, An P, Yu DX, Yu ZJ, Li HX, Sheng HG, Cai L, Xue J, Jing M, Li YX*, Lin X* and Wang F*. Associations between ionomic profile and metabolic abnormalities in human population. PLoS ONE. 2012;7(6):e38845
15. Anderson GJ and Wang F. Essential but toxic: Controlling the flux of iron in the body. Clin Exp Pharmacol Physiol. 2012 Aug;39(8):719-24 (Invited review)
16. Guo L, Lichten LA, Ryu MS, Liuzzi JP, Wang F and Cousins RJ. STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells. Proc Natl Acad Sci USA. 2010 Feb 16;107(7):2818-23
17. Feng YX, Zhao JS, Li JJ, Wang T, Cheng SQ, Yuan Y, Wang F, Wang XF, Xie D. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology. 2010 Feb; 51(2):535-44
18. Mills Eric, Dong XP, Wang F and Xu HX. Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders. Future Medical Chemistry. 2010 Jan;2(1):51-64 ( Invited review)
19. Dong XP, Cheng XP, Mills E, Delling M, Wang F and Xu H. The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endo-lysosomal Iron Release Channel. Nature. 2008 Oct 16;455(7215):992-996
20. Wang F, Paradkar PN, Custodio AO, Ward DM, Fleming MD, Campagna D, Roberts KA, Boyartchuk V, Dietrich WF, Kaplan J, and Andrews NC. Genetic variation in Mon1a protein trafficking modifies macrophage iron loading in mice. Nature Genetics. 2007 Aug;39(8):1025-32
21. Liu S, Suragani RNVS, Wang F, Han A, Zhao W, Fleming MD, Andrews NC and Chen JJ. Deficiency of Heme-Regulated eIF2α Kinase Attenuates Macrophage Maturation Inflammatory Response and Iron Homeostasis. The Journal of Clinical Investigation, 2007:117(11):3296-305
22. Wang F, Lothrop AP, James NG, Griffiths TAM, Lambert LA, Leverence R, Kaltashov IA, Andrews NC, Macgillivray RTA and Mason AB. A novel murine protein with no effect on iron homeostasis is homologous to transferrin and is the putative inhibitor of carbonic anhydrase. Biochemical Journal. 2007;406(1):85-95
23. Mao XQ, Kim BE, Wang F, Eide DJ and Petris MJ. A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity. The Journal of Biological Chemistry. 2007;282(10):6992-7000
24. Lim JE, Jin O, Bennett C, Morgan K, Wang F, Trenor III CC, Gilliland DG, Fleming MD and Andrews NC. A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nature Genetics. 2005;37: 1270-73
25. Mathews W, Wang F, Eide DJ and Van Doren M. Drosophila fear of intimacy encodes a ZIP family zinc transporter functionally related to mammalian ZIP proteins. The Journal of Biological Chemistry. 2005;280(1):787-95
26. Wang F, Kim BE, Dufner-Beattie J, Andrews GK, Petris MJ and Eide DJ. Acrodermatitis enteropathica mutations affect transport activity, localization, and zinc-responsive trafficking of the mouse Zip4 zinc transporter. Human Molecular Genetics. 2004;13(5):563-71
27. Wang F, Dufner-Beattie J, Kim BE, Petris MJ, Andrews GK and Eide DJ. Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters. The Journal of Biological Chemistry. 2004;279(23):24631-39
28. Wang F, Kim BE, Petris MJ and Eide DJ. The mammalian ZIP5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. The Journal of Biological Chemistry. 2004;279(49):51433-41
29. Ellis CD, Wang F, MacDiarmid CW, Clark S, Lyons T and Eide DJ. Zinc and Msc2 zinc transporter protein are required for endoplasmic reticulum function. The Journal of Cell Biology. 2004;166(3):325-35
30. Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ and Petris MJ. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma. The Journal of Biological Chemistry. 279(6):4523-30
31. Dufner-Beattie J, Wang F, Kou YM, Gitschier J, Eide DJ and Andrews GK. The Acrodermatitis Enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated, zinc transporter in mice. The Journal of Biological Chemistry. 2003;278(35): 33474-81
32. Dufner-Beattie J, Langmade SJ, Wang F, Eide DJ and Andrews GK. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. The Journal of Biological Chemistry. 2003;278(50): 50142-50
33. Wang F, Bian W, Kong, L., Zhao F, Guo J, Jing, N. Maternal Zinc Deficiency Impairs Brain Nestin Expression in Prenatal and Postnatal Mice. Cell Research. 2001;11(2): 135-41