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基本信息:

姓名: 王娴
职务:
职称: 副主任医师
学历: 博士
专业: 肿瘤学
所属院系: 邵氏医院
研究方向: 肿瘤早期诊断、预防和化疗
电话: 86006366
信箱:
个人主页:

个人简介:

姓名: 王娴 最高学位:博士 (PhD, 德国)
职位: 医疗小组长,博士研究生导师
地址: 浙江省杭州市庆春东路3号,浙江大学附属邵逸夫医院肿瘤内科邮编:310016
电邮: wangx118@yahoo.com

教育背景:
2002-2005 PhD, University of Karlsruhe, 德国
1989-1996 临床医学学士和肿瘤学硕士, 浙江大学医学院(浙江医科大学七年制)

工作经历:
2011.09- 至今 浙江大学医学院附属邵逸夫医院肿瘤内科
2007.08-2009.11 研究员(Research Fellow),香港城市大学
2006.11-2007.07 副研究员(Research Associate),香港中文大学
2005.11-2006.10 研究助理(Research Assistant),香港中文大学
2005.07-2005.10 博士后, Institute of Toxicology & Genetics, Karlsruhe大学, 德国
2012.01-2002.06 研究助理, Institute of Toxicology & Genetics, Karlsruhe大学, 德国
1998.09-2001.11 主治医师, 浙江大学医学院附属二院肿瘤科
1996.08-1998.08 住院医师, 浙江大学医学院附属二院肿瘤科

学术兼职
浙江省抗癌协会肿瘤转移专业委员会常委
浙江省抗癌协会化疗专业委员会委员
浙江省医学会肿瘤学分会青年委员
浙江省抗癌协会乳腺癌专业委员会委员
浙江省免疫学会肿瘤免疫和生物治疗专业委员委员
浙江省细胞生物学会医学细胞生物专业委员委员
AACR会员
国家自然科学基金同行评议专家
International Journal of Cancer、Chinese-German Journal of Clinical Oncology 等杂志评审专家
World Journal of Gastrointestinal endoscopy 编委

论著
Wang X and Jin H. The epigenetic aspect of gastric carcinoma. Gastric Carcinoma 2011 InTech
Jin H, Ma Y, Shen Q and Wang X. Circulating methylated DNA as biomarkers of cancer detection. Methylation 2012 InTech

发表论文(累积影响因子为155):
第一和通讯作者论文

1. Li J, Jin H, Wang X*.Epigenetic Biomarkers: Epigenetic Biomarkers—Potential Applications in Gastrointestinal Cancers ISRN Gastroenterology 2014 *: 通讯作者
2. Wang Z, Jin W, Jin H, and Wang X*. mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment BioMed Research International 2014 *: 通讯作者 (IF: 2.88)
3. Shen Q, Yao Q, Sun J, Feng L, Lu H, Ma Y, Liu L, Yue Y, Li J, Wang F, Jin H*, Wang X*. Down-regulation of Histone Deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect of doxorubicin FEBS Letters 2014;588:184-91 *: 通讯作者 (IF:3.6)
4. Lu H, Li G, Liu L, Feng L, Wang X* and Jin H. Regulation and function of mitophagy in development and cancer Autophagy 2013;9(11):1-17 *: 通讯作者 (IF: 12.2)
5. Lan T, Wang L, Xu Q, Liu W, Jin H, Mao W, Wang X*, Wang XJ*. Growth inhibitory effect of Cucurbitacin E on breast cancer cells Int J Clin Exp Pathol 2013;6(9):1799-805*: 通讯作者 (IF: 2.2)
6. Wang X, Zhang S, Zhang J, Lam E, Liu X, Sun J, Feng L, Lu H, Yu J, Jin H* Annexin A6 is downregulated through promoter methylation in gastric cancer American Journal of Translational Research 2013;5(5):555-62
7. Lu H, Sun J, Wang F, Feng L, Ma Y, Shen Q, Jiang Z, Sun X, Wang X*, Jin H*. Enhancer of zeste homologue 2 activates wnt signaling through downregulating CXXC finger protein 4 2013; 4:e776 Cell Death & Disease 2013 *: 通讯作者 (IF: 6.0)
8. Shen Q, Jin H and Wang X*. Epidermal stem cells and their epigenetic regulation Int. J. Mol. Sci 2013;14(9):17861-80 (IF: 2.1)
9. Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Lou F, Yang J, Zhang Q, Wang X*, He C*, Pan H* Autophagy and Chemotherapy Resistance: A Promising Therapeutic Target for Cancer Treatment Cell Death & Disease 2013 *: 通讯作者 (IF: 6.0)
10. Feng L, Pan M, Sun J, Lu H, Shen Q, Zhang S, Jiang T, Liu L, Jin W, Chen Y, Wang X*, Jin H*. Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. Journal of Molecular Medicine 2013;91(1):49-58 *: 通讯作者 (IF: 5.2)
11. Wang Y, Ding L, Wang X*, Zhan J, Han W, Feng L, Sun J, Jin H and Wang XJ*. Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells American Journal of Translational Research 2012;4(1):44-51 *: 通讯作者
12. Wang L, Wang X*, Wang XJ, Pan J, Lu HQ, Zhang SJ, Lin XY, Lam EK, Cui Y, Yu J and Jin HC*. Klotho is silenced through promoter hypermethylation in gastric cancer American Journal of Cancer Research 2011;1(1):111-119 *: 通讯作者
13. Lam EK, Wang X*, Shin V, Zhang S, Morrison H, Sun J, Ng EK, Yu J and Jin H*. A microRNA contribution to aberrant Ras activation in gastric cancer. American Journal of Translational Research 2011;3(2):209-218 *: 通讯作者
14. Feng LF, Wang X* and Jin HC*. Rabbit monoclonal antibody: potential application in cancer therapy American Journal of Translational Research 2011;3(3):269-274 *: 通讯作者
15. Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X*, Wang LJ*. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer Tumor Biology 2011;32(4):729-735 *: 通讯作者 (IF: 2.2)
16. Wang X and Jin H. The epigenetic basis of Warburg effect Epigenetics 2010; 5(7):566-568 (IF: 4.5)
17. Liu X*, Wang X*, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ and Jin HC. Warburg effect revisited: An epigenetic link between glycolysis and gastric carcinogenesis Oncogene 2010;29:442-450 (IF: 7.2) *: 共同第一作者
18. Wang X, Lau KK, So LK and Lam YW. CHD5 is down-regulated through promoter hypermethylation in gastric cancer. Journal of Biomedical Science 2009;Oct 19;16:95 (IF: 2.0)
19. Wang X, Lam EK, Zhang JB, Jin HC and Sung JJ. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers Biochem Bioph Res Com 2009; Jun 14;387(2):376-380 (IF: 2.7)
20. Jin H.*, Wang X.*, Wong AHY, Chan ATC, Tao Q. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas. Oncogene, 2007;Nov 22;26(53):7490-8 (IF: 7.2) *: 共同第一作者
21. Wang X. and Johnsson N. Protein kinase CK2 phosphorylates Sec63p to stimulate the assembly of the endoplasmic reticulum protein translocation apparatus. Journal of Cell Science 2005; 118: 723-32 (IF: 6.2)

其它论文
22. Yao Q, Ye X, Gu J, Wang L, Fu T, Wang Y, Lai Y, Wang Y, Wang X, Jin H, Guo Y*. Protective effect of Curcumin on chemotherapy-induced intestinal dysfunction Int J Clin Exp Pathol 2013 (IF: 2.2)
23. Sun J, Lu H, Wang X and Jin H*. MicroRNAs in hepatocellular carcinoma: regulation, function and clinical Implications. The Scientific World Journal: Gastroenterology 2013;2013:924206 (IF: 1.5)
24. MaY, Wang X and Jin H*. Methylated DNA and microRNA in body fluids as biomarkers for cancer detection. Int. J. Mol. Sci 2013 May 16;14(5):10307-31 (IF: 2.1)
25. Liang Y, Wang X, So K, Lam Y and Li Z. Novel nucleolar isolation method reveals rapid response of human nucleolar proteomes to serum stimulation Journal of Proteomics 2012; 77:521-30 (IF: 4.9)
26. Hong W, Wang X, Yu X, Chen B, Ding G and Zhang Y. Palatine tonsillar metastasis of lung cancer during chemotherapy Int J Clin Exp Pathol 2012;5(5):468-471 (IF: 2.2)
27. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, Lam E, Liu X, Zhang J, Zhou T, Yu J, Jin H and Si J. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis Molecular Medicine 2012 May 9;18(1):389-400 (IF: 5.9)
28. Zhang S, Jiang T, Feng L, Sun J, Lu H, Wang Q, Pan M, Huang D, Wang X, Wang L and Jin H. Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha Journal of Molecular Medicine 2012 Sep;90(9):1069-77 (IF: 5.2)
29. Han W, Sun J, Feng L, Wang K, Li D, Pan Q, Chen Y, Jin W, Wang X, Pan H and Jin H. Autophagy Inhibition Enhances Daunorubicin-induced Apoptosis in K562 cells PLoS One 2011;e028491 (IF: 4.8)
30. Han W, Pan H, Chen Y, Sun J, Wang Y, Li J, Ge W, Feng L, Lin X, Wang XJ, Wang X, Jin H. EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells PLoS One 2011;6(6):e18691 (IF: 4.5)
31. Gan L, Chen S, Zhong J, Wang X, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L and Jin H. ZIC1 Is Downregulated through Promoter Hypermethylation, and Functions as a Tumor Suppressor Gene in Colorectal Cancer. PLoS One. 2011 Feb 15;6(2):e16916 (IF: 4.8)
32. Shu XS, Geng H, Li L, Ying J, Ma C, Wang Y, Poon FF, Wang X, Ying Y, Yeo W, Srivastava G, Tsao SW, Yu J, Sung JJ, Huang S, Chan AT and Tao Q. The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors. PLoS One. 2011 Nov 8;6(11):e27346 (IF: 4.8)
33. Li L, Tao Q, Jin H, Hasselt AV, Poon FF, Wang X, Zeng MS, Jia W, Zeng YX, Chan AT, Cao Y. The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma Clin Cancer Res. 2010;16(11):2949-58 (IF: 6.8)
34. Liu X, Lam EK, Wang X, Zhang JB, Cheng YY, Lam YW, Ng EK, Yu J, Chan FK, Jin H and Sung JJ. Promoter hypermethylation mediates downregulation of thiamin receptor SLC19A3 in gastric cancer Tumor Biology 2009;Oct 7;30(5):242-248 (IF: 2.2)
35. Wang LJ, Jin HC*, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ*. ZIC1 is downregulated through promoter hypermethylation in gastric cancer Biochem Bioph Res Com 2009;Feb 20;379(4):959-63 (IF: 2.7)
36. Lee KY, Geng H, Ng KM, Yu J, van Hasselt A, Cao Y, Zeng YX, Wong AH, Wang X, et al. Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas. Oncogene. 2008;Sep 4;27(39):5267-76. (IF: 7.2)
37. Yu J, Tao Q, Cheung K, Jin H, Poon FF, Wang X., et al. Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors Hepatology 2008;Auguest;48(2):508 (IF: 11.4)
38. Jin H., Wang X., Wong AHY, Chan ATC, Cullen P., Tao Q. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proceedings of the National Academy of Sciences of USA 2007;Jul 24;104(30):12353 (IF: 9.5)