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基本信息:

姓名: 章淑芳
职务:
职称:
学历: 博士
专业: 干细胞与再生医学
所属院系: 基础医学系
研究方向: 干细胞微环境调控,力学与细胞命运的关联研究
电话: 0571-88208261
信箱: zhangshufang@zju.edu.cn
个人主页:

个人简介:

2009年博士毕业于新加坡国立大学生物工程系,现任职于浙江大学医学院,主要从事细胞微环境控制的研究。利用微细加工制造技术控制原代肝脏细胞微环境,创新建立了体外高通量药物筛选平台装置,已用于和强生公司合作课题研究。利用工程化手段控制胚胎干细胞微环境,建立其体外批量分化的平台。共发表论文12篇,撰写英文专著章节1篇,申请并获批国际专利1项,目前主持国家自然科学基金青年基金项目等课题4项,主要参与5项。获得2009年度和2010年度浙江大学医学院基础医学系优秀博士后奖,2012年浙江大学“求是青年学者”。

研究课题:
1. 基于微细加工制造技术建立人胚胎干细胞体外大规模心肌定向分化平台的研究,中国博士后基金,2009-2011,负责人
2. 微细加工技术精确调控人胚胎干细胞向软骨分化的效应及机制研究,国家自然科学基金青年基金项目, 2011-2013,负责人
3. 基于微生物反应器建立胚胎干细胞软骨定向分化平台的研究,中央高校基本业务费青年创新基金,2011-2012,负责人
4. 材料拓扑结构调控干细胞定向分化及其机制研究,浙江省科技厅公益技术研究项目,2012-2012,负责人
5. 浙江大学2012年优秀青年教师资助(紫金计划)
6. 浙江大学“求是青年学者”

论文发表:
1)Shufang Zhang, Yangzi Jiang, Wei Zhang, Longkun Chen, Tong Tong, Wanlu Liu, Hong Wei Ouyang, Xiaohui Zou. Neonatal Desensitization Supports Long Term Survival and Functional Integration of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells in Rat Joint Cartilage without Immunosuppresssion, submitted to Stem Cells and Development, 2012 Aug 14. [Epub ahead of print]..
2)Shufang Zhang, Wenhao Tong, Baixue Zheng, Thomas A Susanto, Lei Xia, Chi Zhang, Abhishek Ananthanaryanan, Xiaoye Tuo, Sakban Rashidah Binte, Rui Rui Jia, Ciprian Iliescu, Kah Hin Chai, Michael McMillian, Shali Shen, Hwa Liang Leo, Hanry Yu, A robust high-throughput sandwich cell-based drug screening platform, Biomaterials, 2011,32(4):1229-41.
3)Shufang Zhang, Yang Zi Jiang, Hong Wei Ouyang, “Cartilage injuries of Women in Sports: the Present and Future Therapeutics”, International Journal of Medical and Biological Frontiers, 2011, 17(6):595-610.
4)Shufang Zhang, Lei Xia, Chiang Huen Kang, Guangfa Xiao, Siew Mine Ong, Yi Chin Toh, Hwa Liang Leo, Danny van Noort, Shyi Herng Kan, Hui Huan Tang and Hanry Yu, Microfabricated silicon nitride membranes for hepatocyte sandwich culture, Biomaterials, 2008, 29(29): 3993-4002
5)章淑芳,章恩明,郑筱祥, 胚体培养对小鼠ES 细胞定向神经分化的影响研究, 生物医学工程学杂志,2006, 23(3): 620-624
6)Zhang Wei, Chen Jialin, Zhang Shufang, Ouyang HongWei, Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair, Arthritis Res Ther. 2012 Aug 31;14(4):221. [Epub ahead of print].
7)Xia L, Arooz T, Zhang S, Tuo X, Xiao G, Susanto TA, Sundararajan J, Cheng T, Kang Y, Poh HJ, Leo HL, Yu H. Hepatocyte function within a stacked double sandwich culture plate cylindrical bioreactor for bioartificial liver system, Biomaterials. 2012, 33(32):7925-32.
8)Yangzi Jiang, Shufang Zhang, Linlin Wang, Hongwei Ouyang. Cell transplantation for articular cartilage defects: principles of past, present and future practice. Cell Transplantation, 2011, 20(5): 593-607.
9)Siew-Min Ong, Ziqing Zhao, Talha Arooz, Deqiang Zhao, Shufang Zhang, Tiehua Du, Martin Wasser, Danny van Noort and Hanry Yu, Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies, Biomaterials, 2010, 31(6): 1180-1190.
10)Chi Zhang, Ser-Mien Chia, Siew-Min Ong, Shufang Zhang, Yi-Chin Toh, Danny van Noort and Hanry Yu, The Controlled Presentation of TGF-β1 to Hepatocytes in a 3D-Microfludic Cell Culture System, Biomaterials, 2009, 30 (23-24): 3847-3853.
11)Danny van Noort, Siew Min Ong, Chi Zhang, Shufang Zhang, Talha Arooz and Hanry Yu, Stem cells in microfluidics, Biotechnol Prog., 2009, 25(1): 52-60.
12)Enming Zhang, Xiaolong Li, Shufang Zhang, Liangqiang Chen and Xiaoxiang Zheng, Cell cycle synchronization of embryonic stem cells: Effect of serum deprivation on the differentiation of embryonic bodies in vitro, Biochem Biophys Res Commun., 2005, 333(4): 1171-1177.

书籍章节:
Shufang Zhang, Yang Zi Jiang, Hong Wei Ouyang, Book chapter “Therapies for Cartilage injuries of Women in Sports: the Way to Citius, Altius, and Fortius”, Book “Women in Sports”, Nova Publishers, 2010, ISBN: 978-1-61728-161-7.

专利:
Hanry Yu, Shufang Zhang, Hwa Liang Leo, Apparatus for Cell or Tissue Culture, PCT Patent Application No. PCT/SG2010/000120, Filing date: 26 Mar 2010, Publication Number-WO 2010/110754 A1, Publication Date-30 Sept 2010.