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基本信息:

姓名: 戴海斌
职务: 副主任
职称: 主任药师
学历: 博士
专业: 神经药理学
所属院系: 浙医二院
研究方向: 神经血管单元在兴奋性脑损伤中的作用与干预
电话: 0571-87783891
信箱: haibindai@zju.edu.cn
个人主页:

个人简介:

戴海斌,男,博士,主任药师,浙江大学医学院博士研究生导师。目前任浙江大学医学院附属第二医院药学部副主任。主要从事神经药理以及脑血管病的发病机制和防治研究,以及临床药学等工作。曾受国家留学基金委员会资助在美国哈佛医学院麻省总医院作访问学者工作一年。目前已发表SCI论文34篇,其中第一/通讯作者文章24篇。曾获省自然科学奖、省科技进步一等奖各一次。担任Neuroscience LettersPlanta MedicaPharmaceutical BiologyMolecules等杂志的审稿专家。

1、社会兼职

·           中国医药教育协会临床合理用药专业委员会 副主任委员

·           中国药理学会神经精神药理学分会 委员

·           中国药理学会分子与生化药理学分会 委员

·           中国药理学会药源性疾病分会神经病学组 委员

·           中国医疗保健国际交流促进会循证医学分会药物经济学评价学组 委员

·           浙江省药理学会药物治疗监测研究分会 副主任委员

·           浙江省医学会临床药学分会 青年委员

2、大学开始受教育经历

·           1993.9~1998.6,中国药科大学,药理学系,学士学位。

·           2003.9~2008.6,浙江大学医学院,药理学系,博士学位。

3、研究工作经历

·           1998.8~   浙江大学医学院附属第二医院,从事脑损伤与修复的分子药理学研究。

期间曾主持以下课题研究

(1)       Annexin A2-ANXA2R通路在阿尔茨海默病脑血管功能障碍中的作用和机制研究,2017.1-2019.12,国家卫生和计划生育委员会科研基金-浙江省医药卫生重大科技计划重点项目,WKJ-ZJ-1719

(2)       HDAC9在缺血性脑损伤中的作用和机制研究,2016.1-2019.12,国家自然科学基金面上项目,81573402

(3)       重组annexin A2治疗缺血性脑卒中的临床前药效学研究,2014.7--2016.12,浙江省科技厅项目,2014C33185

(4)       补体C3在糖尿病合并脑缺血损伤中的作用及对TLR2/4信号通路的影响, 2014.1-2017.12,国家自然科学基金面上项目,81373391

(5)       Annexin A2糖基化在高血糖加重缺血性脑损伤中的作用及机制研究,2012.1-2015.12,国家自然科学基金面上项目,81173040

(6)       Annexin A2对糖尿病大鼠脑缺血后血管再生的作用及机制研究,2011.6-2013.12, 浙江省卫生厅面上项目,2011KYA065

(7)       羟基红花黄色素A干预蛋白非酶糖基化和改善糖尿病性脑血管病变的机理研究,2012.6-2014.12, 浙江省卫生厅青年骨干人才项目,2012RCA027

(8)       AGEs/RAGE/NFκB在糖尿病性脑血管病中的作用及HSYA的干预研究,2012.6-2014.12, 浙江省中医药科研项目,2012ZB091

(9)       组胺在脑缺血预处理中的作用及对缺氧诱导因子-1的影响,2007.1-2009.12,国家自然科学基金青年科学基金项目,30600757已结题

(10)   促红细胞生成素纳米颗粒剂对脑缺血治疗作用的开发研究,2008.1-2010.12,浙江省科技厅重点项目,2008C23080已结题

(11)   天麻素对脑缺血保护作用的分子机制研究,2008.1-2009.12,浙江省中医药青年课题研究计划,2008YA021已结题

另外,以主要人员参与了国家自然科学基金重点项目“中枢组胺及其受体对脑缺血后星形胶质细胞功能和胶质疤痕形成的作用及其机制研究”81030061PI:陈忠教授),参与了国家自然科学基金(30801392, 30701015, 30600194)及多项省部级课题的研究。具有丰富的研究经验和基础。

·           2009.4~2010.4,美国哈佛医学院麻省总医院访问学者。主要从事高血糖神经损伤的机制与保护研究。

4、科研成果

·           获奖:

(1)       中华医学会临床药学分会 2016年全国优秀临床药师

(2)       陈忠,胡薇薇,张翔南,戴海斌,张世红. 缺血性脑损伤的药物治疗新靶点及意义,浙江省自然科学奖一等奖(2015-Z-001-R04

(3)       戴海斌,浙江省药学会医药科技奖,一等奖,2015年。

(4)       戴海斌,第十八届SERVIER青年药理学工作者,中国药理学会,2014

(5)       罗晓星、陈忠、李明凯、胡薇薇、何功浩、范彦英、胡 静、张世红、马雪、戴海斌、孟静茹. 神经源性组胺新作用的发现及其意义,陕西省科学技术奖一等奖2011-1-31-R10),2011

(6)       戴海斌.第二届林百欣高科技奖二等奖. 2007

(7)       陈忠、魏尔清、罗建红、张纬萍、胡薇薇、金春雷、戴海斌、张力三、黄育文. 脑内组胺系统在脑疾病发生与治疗中的意义,浙江省科学技术奖二等奖No.0602114), 2006

(8)       戴海斌、陈忠. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/cyclic AMP/protein kinase A and H3 receptor/GABA release pathways,第十四届浙江省自然科学优秀论文奖二等奖(No.072100004),2007

·           近年来发表的主要论文:

1         Xu H, Ping Y, Lin H, He P, Li W, Dai H. Antiplatelet Strategies and Outcomes in Patients with Noncardioembolic Ischemic Stroke from a Real-World Study with a Five-Year Follow-Up. Transl Stroke Res. 2017 Jun;8(3):228-233. 4.503

2         Xu H, Cai S, Dai H. Characteristics of Infective Endocarditis in a Tertiary Hospital in East China. PLoS One. 2016 Nov 18;11(11):e0166764. 3.057

3         Lv QH, Xu LC, Dai HB. Acamprosate protects rat brain against middle-cerebral-artery-occlusion-induced ischemic injuries through anti-oxidative activities. Int J Clin Exp Med. 2016; 9(8): 16185-91. 1.075

4         Hu Y, Ping Y, Li L, Xu H, Yan X, Dai H*. A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients. J Infect Dev Ctries. 2016 Mar 31;10(3):208-13. 1.138

5         Li W, Chen Z, Yan M, He P, Chen Z, Dai H*. The protective role of Isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen glucose deprivation. J Neurochem. 2016 Feb;136(3):651-9.

6         Zhang J, Wu G, Dai H*. The matricellular protein CCN1 regulates TNF-α induced vascular endothelial cell apoptosis. Cell Biol Int. 2016 Jan;40(1):1-6.. 1.933

7         Fang L, Li X, Zhong Y, Yu J, Yu L, Dai H*, Yan M*. Autophagy protects Human Brain Microvascular Endothelial Cells against Methylglyoxal-induced Injuries: in parallel with Cerebral Ischemic Model in Diabetic Rats. J Neurochem. 2015 135(2):431-40. 4.281

8         Zhang S, Hu Y, Huang Y, Xu H, Wu G, Dai H*. Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer. Oncol Lett. 2015 Jun;9(6):2572-2576. 1.554

9         Xu H, He Y, Xu L, Yan X, Dai H*. Trends and patterns of five antihypertensive drug classes between 2007 and 2012 in China using hospital prescription data. Int J Clin Pharmacol Ther. 2015 Jun;53(6):430-7. 1.223

10     Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, Dai H, Hu WW, Zhang Z, Chen Z. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. 11.753

11     Cai H, Dai H, Hu Y, Yan X, Xu H. Pharmacist care and the management of coronary heart disease: a systematic review of randomized controlled trials. BMC Health Serv Res. 2013 Nov 4;13(1):461. 1.773

12     Hu Y, Li L, Li W, Xu H, He P, Yan X, Dai H*. Combination antibiotic therapy versus monotherapy for Pseudomonas aeruginosa bacteraemia: A meta-analysis of retrospective and prospective studies. Int J Antimicrob Agents. 2013.42: 492–496. 4.415

13     Li W, Xu H, Hu Y, He P, Ni Z, Xu H, Zhang Z, Dai H*.  Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress. PLoS ONE. 2013. 8(9): e76025. 3.73

14     Li W, Liu J, He P, Ni Z, Hu Y, Xu H, Dai H*. Hydroxysafflor yellow A protects methylglyoxal-induced injury in the cultured human brain microvascular endothelial cells. Neurosci Lett. 2013. 549:146–150. 2.026

15     Dai H*, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X*. Dysfunction of annexin A2 contributes to hyperglycemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Mar 21;109(6): 1070-8. 6.094

16     Xu H, Cai H, Qian Z, Xu G, Yan X, Dai H*. Dosing practice of low molecular weight heparins and its efficacy and safety in cardiovascular inpatients: a retrospective study in a Chinese teaching hospital. BMC Cardiovasc Disord. 2012 Dec 5;12(1):118. 1.457

17     Ni Z, Zhuge Z, Li W, Xu H, Zhang Z, Dai H*. Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation endproducts in vitro. Biol Pharm Bull. 2012;35(11):2050-3. 1.849

18     Hu Y, Ren J, Zhan M, Li W, Dai H*. Efficacy of rifaximin in prevention of traveler diarrhea: a meta-analysis of randomized, double-blind, placebo-controlled trials. J Travel Med. 2012;19(6):352-6. 1.683

19     Zhang F, Ding T, Yu L, Zhong Y, Dai H, Yan M. Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol. 2012;64(1):120-7. IF:1.918

20     Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 ;43(2):567-70.IF:5.756

21     Bie X, Chen Y, Zheng X, Dai H. The role of crocetin in protection following cerebral contusion and in the enhancement of angiogen esis in rats. Fitoterapia. 2011;82(7):997-1002. IF:1.899

22     Yan M, Dai H, Ding T, Dai A, Zhang F, Yu L, Chen G, Chen Z. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochem Int. 2011; 58(5):549-57.IF:3.541),共同第一作者

23     Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab. 2011;31(1):305-14. IF:5.457),共同第一作者

24     Bie X, Han J, Dai H*. Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats. J Asian Nat Prod Res. 2010; 12(3):239-47. IF:0.608通讯作者

25     Fu Q, Dai H, He P, Hu W, Fan Y, Zhang W, Chen Z. The H3 receptor antagonist clobenpropit protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Pharmazie. 2010;65(4):257-60. IF:0. 812

26     Dai H, Zhang Z, Zhu Y, Shen Y, Hu W, Huang Y, Luo J, Timmerman H, Leurs R, Chen Z. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/cyclic AMP/protein kinase A and H3 receptor/GABA release pathways. J Neurochem 2006;96:1390-400. IF:4.260

27     Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol 2007;563:117-23. IF:2.522

28      Xu X, Dai H, Shi Y. Erythropoietin protects primary cultures of rat cortical neurons from hypoxia-induced toxicity through attenuating both glutamate release and NMDA receptor evoked neurotoxicity pathway. Pharmazie 2009;64:210-3. IF:0. 812

29      Fu Q, Dai H, Hu W, Fan Y, Shen Y, Zhang W, Chen Z. Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Cell Mol Neurobiol 2008;28:307-16. IF:2.107

30      Shen Y, Fan Y, Dai H, Fu Q, Hu W, Chen Z. Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neurosci Lett 2007;414:145-9. IF:1.925

31      Bie X, Chen Y, Han J, Dai H, Wan H, Zhao T. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pac J Clin Nutr 2007;16 Suppl 1:305-8. IF:1.214

32      Shen Y, Hu WW, Fan YY, Dai HB, Fu QL, Wei EQ, Luo JH, Chen Z. Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors. Biochem Pharmacol 2007;73:709-17. IF:4.254

33      Hu W, Fan Y, Shen Y, Yang Y, Dai H, Fu Q, Chen Z. Mast cell-derived mediators protect against oxygen-glucose deprivation-induced injury in PC12 cells and neurons. Neurosci Lett 2007;423:35-40. IF:1.925

34      Gong YX, Wang HJ, Zhu YP, Zhang WP, Dai HB, Zhang SH, Wei EQ, Chen Z. Carnosine ameliorates morphine-induced conditioned place preference in rats. Neurosci Lett 2007;422:34-8. IF:1.925