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基本信息:

姓名: 张丹丹
职务:
职称: 副教授
学历: 博士
专业: 遗传学
所属院系: 基础医学系
研究方向: 复杂疾病的生物学机制研究
电话: 0571-88208138
信箱: dandanz@zju.edu.cn
个人主页:

个人简介:

张丹丹,女,出生于1981年,博士,浙江大学医学院副教授,硕士生导师,研究方向为复杂疾病的生物学机制研究。于2002年7月在华东师范大学获学士学位(专业:生物化学);于2007年7月在复旦大学获博士学位(专业:遗传学);于2007年11月-2010年8月期间,在美国芝加哥大学进行博士后训练,主要从事甲基化和复杂疾病的遗传学研究。于2010年9月到浙大任职。
工作研究领域
复杂疾病遗传学,包括大肠癌和代谢综合征等。目前参与国家重大课题一项《上皮间质转化在结直肠癌转移中的作用及机制》。
主要发表的论文:
1.Dandan Zhang, Yudong Qian, Nirmala Akula, Ney Alliey-Rodriguez, Jinsong Tang, The Bipolar Genome Study, Elliot S. Gershon, Chunyu Liu. Accuracy of CNV Detection from GWAS Data. PLoS One. 2011 Jan 13;6(1):e14511.

2. Dandan Zhang*, Lijun Cheng*, Judith A Badner, Chao Chen, Qi Chen, Wei Luo, Margot
Redman, David W Craig, Elliot S Gershon, Chunyu Liu. Genetic control of individual differences in gene-specific methylation in human. Am J Hum Genet. 2010, 86(3):411-9 (*equal contribution authors)

3. Dandan Zhang, Lijun Cheng, David W Craig, Margot Redman, Chunyu Liu. Cerebellar telomere length and psychiatric disorders. Behav Genet. 2010 40(2):250-4.

4. Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey-Rodriguez, et al. Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder. Mol Psychiatry. 2009 14(4):376-80.

5. Dandan Zhang, Chunhong Shao, Minhua Shao, Pengrong Yan, Yi Wang, Yixiao Liu, Wenhong Liu, Tong Lin, Yuying Xie , Yingnan Zhao, Daru Lu,Yifeng Li and Li Jin. Effect of μ-opioid Receptor Gene Polymorphisms on Heroin-induced Subjective Responses in a Chinese Population. Biol Psychiatry. 2007 61(11):1244-51.

6. *Yifeng Li, *Dandan Zhang, *Wei Jin, Chunhong Shao, Pengrong Yan, Yuying Xie, Daru Lu, Wei Huang, Li Jin.E487K Polymorphism of ALDH2 Is Responsible For Efficacy Variation of Sublingual Nitroglycerin in Chinese. Journal of Clinical Investigation. 2006 116(2): 506-11. (*equal contribution authors)

7. Rong Lin, Ying Wang, Yi Wang, Wenqing Fu, Dandan Zhang, Hongxiang Zheng, Ting Yu, Ying Wang, Min Shen, Rong Lei, Hong Wu, Aijun Sun, Ruifang Zhang, Xiaofeng Wang, Momiao Xiong, Wei Huang, Li Jin. Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. Pharmacogenet Genomics. 2009 19(4):310-318.

8. Ling Xu, Fan Zhang, Dan-dan Zhang, Xing-dong Chen, Ming Lu, Ren-yong Lin, Hao Wen, Li Jin and Xiao-feng Wang. OPRM1 Gene Is Associated With BMI in Uyghur Population. Obesity (Silver Spring). 2009 17(1):121-5.

9. Yifeng Li, Chunhong Shao, Dandan Zhang, Pengrong Yan, Yuying Xie, Daru Lu, Li Jin. The Effect of Dopamine D2, D5 Receptor and Transporter (SLC6A3) polymorphisms on the Cue-Elicited Heroin Craving in Chinese. American Journal of Medical Genetics. 2006 141(3): 269-73.

10. Chunhong Shao, Yifeng Li, Kaida Jiang, Dandan Zhang,Yifeng Xu,Ling Lin, QiuyingWang,Min Zhao, Li Jin. Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese. Psychopharmacology (Berl). 2006 Jun; 186(2):185-90.

会议摘要
D. Zhang, L. Cheng, C. Liu. Telomere length in brain and psychiatric disorders. 58th Annual Meeting of the American Society of Human Genetics. Philadelphia, PA, November 11-15, 2008. Abstract #1801

Dandan Zhang, Yudong Qian, Nirmala Akula, Elliot S. Gershon, Chunyu Liu.
CNV Detection From GWAS data: Comparison of Four Software Suites. XVII World Congress of Psychiatric Genetics, San Diego, SD, November 4-8, 2009, Abstract #127.

Dandan Zhang, Jinsong Tang, Lijun Cheng, Fabio Pibiri, Chao Chen, Chunling Zhang, Judith Badner, Elliot S. Gershon, Chunyu Liu. Rare CNVs Affect Gene Expression in Human Cerebellum. XVIII World Congress of Psychiatric Genetics, Athens, Greece, October 3-7, 2010.

大会报告
Genetic control of individual differences in gene-specific methylation in human brain.XVII World Congress of Psychiatric Genetics, San Diego, SD, November 4-8, 2009.