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基本信息:

姓名: 徐立红
职务:
职称: 教授
学历: 博士研究生
专业: 生物化学与分子生物学
所属院系: 基础医学系
研究方向: 环境污染物影响细胞信号转导及细胞凋亡的机制
电话: 0571-88208265
信箱: xulihong@zju.edu.cn
个人主页:

个人简介:

博士,1982年毕业于武汉大学生物系生物化学专业,先后在美国、日本、香港进行合作研究及做博士后。1985-1999年在中国科学院水生生物研究所从事生态毒理学的研究工作。1999年8月作为人才引进到浙江大学从事环境毒理学和生化毒理学研究工作, 2009年入选浙江省151人才工程计划重点资助人员。 中国环境诱变剂学会理事,《癌变.畸变.突变》杂志编委,浙江省生化学会理事。已发表论文120余篇,获浙江省科技进步二等奖、三等奖各一项,授权发明专利6项。
现阶段承担课题为国家自然科学基金项目“用源自多细胞通路变化建立的细胞应答网络评价环境污染物的毒性效应”、“微囊藻毒素作用中PP2A亚基表达水平及全酶胞内定位与PP2A活性的相关性研究”国家科技重大专项子课题“高藻湖泊型原水取水口藻类拦截与生物控制关键技术研究”。研究方向主要包括
1.蛋白磷酸酶2A在微囊藻毒素致毒过程中的作用。
2.蛋白磷酸酶2A与疾病相关性研究。
3.环境污染物引起的细胞信号转导网络的改变及其细胞学效应。
4.噬藻体控制水华蓝藻的基本方法与技术。

近年发表论文:
1.Fu Wenyu, Chen Jiaping, Wang Xiumin and Xu Lihong. Altered expression of p53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro, Toxicon,2005,46: 171-177
2.Fu Wenyu, Xu Lihong, Yu Yingnian. Proteomic analysis of cellular response to microcystin in human amnion FL cells, Journal of Proteome Research, 2005,4,2207-2215
3.Liu Huigang, Wang Yan, Lian Lingjun and Xu Lihong. Tributytin induces DNA damage as well as oxidative damage in rats, Environmental Toxicology,2006,21,166-171
4.Jin XU, Lin-dan JI, Li-hong XU. Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3. Toxicology Letters,2006,166:160-167
5.Xiao-Feng Wang, Ming-Luan Xing, Ying Shen, Xin Zhu, Li-Hong Xu. Oral administration of Cr(VI) induced oxidative stress, DNA damage and apoptotic cell death in mice,Toxicology,2006,228:12-23
6.Zhu Xin, Mingluan Xing, Jianlin Lou, Xiaofeng Wang, Wenyu Fu, XU Lihong Apoptotic related biochemical changes in human amnion cells induced by tributyltin,Toxicology,2007,230:45-52
7.Liu Huigang, Li-Hong Xu. Garlic oil prevents tributyltin-induced oxidative damage in vivo and in vitro. Journal of Food Protection. 2007,70(3):716-721
8.Liu Huigang, Guo Zonglou,Lihong Xu and Stephen Hsu. Protective effect of green tea polyphenols on tributyltin-induced oxidative damage detected by in vivo and in vitro models,Environmental Toxicology ,2008,23(1):77-83
9.Xing Mingluan,Wang Xiaofeng, Lihong Xu. Alteration of proteins expression in apoptotic FL cells induced by MCLR,Environmental Toxicology 23(4): 451-8
10.Jin Xu, Ling-jun Lian, Chen Wu, Xiao-feng Wang, Wen-yu Fu, Li-hong Xu Lead induces oxidative stress, DNA damage and alteration of p53,Bax and Bcl-2 expressions in mice. Food and Chemical Toxicology,2008,46(5): 1488-1494
11.Huang Pu,Xu Lihong,Oral administration of cyanobacterial bloom extract induced the altered expression of the PP2A, Bax and Bcl-2 in mice,Environmental Toxicology,2008, 23(6):688-693
12.Wenyu Fu,Yu Yingnian,Xu Lihong. Identification of temporal differentially expressed protein responses to microcystin in human amniotic epithelial cells,Chemical Research in Toxicology,2009,22(1):41-51
13.Ming-luan Xing, Xiao-feng Wang, Xin Zhu, Xu-dong Zhou, Li-hong Xu,Morphological and Biochemical Changes Associated with Apoptosis Induced by Okadaic Acid in Human Amniotic FL Cells Environmental Toxicology 24: 437–445, 2009
14.Xu Jin,Ji Lindan,Xu Lihong,Endoplasmic Reticulum May Not Be Involved in the Lead-Induced Apoptosis in PC 12 Cells In Vitro,Environmental Toxicology,2010,25: 55–60
15.Xiao-Feng Wang, Xiao-Ming Lou, Ying Shen, Ming-Luan Xing, Li-Hong Xu. Apoptotic-related protein changes induced by hexavalent chromium in mice liver. Environmental Toxicology 2010,25: 77–82
16.Huang Pu, Qun Zheng and Lihong Xu, The apoptotic effect of oral administration of microcystin-RR on mice liver. Environmental Toxicology, 2010.