移动站  | 2017年09月23日 星期六
用户登录

当前位置:首页 >> 师资队伍

基本信息:

姓名: 胡讯
职务:
职称: 教授
学历:
专业: 肿瘤学兼跨生化与分子生物学、生物信息学
所属院系: 浙医二院
研究方向: 1.肿瘤生物学 2.抗癌药研发
电话: 87783656
信箱: huxun@zju.edu.cn
个人主页:

个人简介:

国家教育部第四批长江学者,求是教授。研究方向(1)抗肿瘤药物的研究,克服肿瘤耐药性的药物和抗肿瘤转移的候选药物;(2)肿瘤细胞代谢的机理。近期发表的论文如下:
1. Han W,Xie J, Li L, Liu Z, Hu X* Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis 14:674-686, 2009
2. Xuan Y, Hu X*. Naturally-occurring shikonin analogues- a class of necroptotic inducers that circumvent cancer drug resistance. Cancer lett 274-233-242, 2009
3. Li L, Pan Q, Han W, Liu Z, Li L, Hu X*.Schisandrin B Prevents Doxorubicin-Induced Cardiotoxicity via Enhancing Glutathione Redox Cycling.Clin Cancer Res. 2007, 13(22):6753-60
4.Hu X*, Han W, Li L. Targeting the weak point of cancer by induction of necroptosis.Autophagy. 2007,3(5):490-2.
5. Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo J, Hu X*. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther. 2007, 6(5):1641-9
6. Li L, Han W, Gu Y, Qiu S, Lu Q, Jin J, Luo J, Hu X*. Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res. 2007, 67(10):4894-903.
7. Zhang K, Han W, Zhang R, Xu X, Pan Q, Hu X*. Phenylobacterium zucineum sp. nov., a facultative intracellular bacterium isolated from a human erythroleukemia cell line K562. Syst Appl Microbiol. 2007, 30(3):207-12.
8. Pan Q, Lu Q, Zhang K, Hu X*. Dibenzocyclooctadiene – a class of novel inhibitors of P-glycoproteins. Cancer Chemother Pharmacol 58:99-106, 2006.
9. Li L, Pan Q, Sun M, Lu Q, Hu X* Dibenzocyclooctadiene-a class of novel inhibitors of multidrug resistance. Life Sciences. 80:741-748,2007。
10. Li L, Lu Q, Hu X*. Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells. Biochem Pharmcol 71:584-595, 2006.
11. Pan Q, Wang T, Lu Q, Hu X*. Schisandrin B – a novel inhibitor of P-glycoprotein. Biochem Biophys Res Comm. 335:406-411, 2005.
12. Sun M, Xu X, Lu Q, Pan Q, Hu X*. Schisandrin B – a Dual Inhibitor of P-glycoprotein and Multidrug Resistance-associated Protein 1. Cancer Lett , 246:300-307,2007
13. Xu D, Lu Q, Hu X*. Downregulation of P-glycoprotein in expression in MDR brease cancer cell MCF-7/ADR by honokiol. Cancer Lett. 2006, 243:274-280, 2006
14. Chen YD, Zheng S, Yu JK, Hu X*. Artificial neural networks analysis of surface-enhanced laser desorption/ionization mass spectra of serum protein pattern distinguishes colorectal cancer from healthy population. Clin Cancer Res 2004, 10(24):8380-5.