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基本信息:

姓名: 王秀君
职务: PI、博士生导师
职称: 教授
学历: 博士
专业: 分子药理学
所属院系: 基础医学系
研究方向: 基于重大疾病信号通路的分子药理研究
电话: 0571-88981270
信箱: xjwang@zju.edu.cn
个人主页:

个人简介:

教育和研究经历:
1986: 兰州大学生物学学士学位
1996: 英国伦敦大学(London University, UK)博士学位
2000-2009: 英国肿瘤研究院(Cancer Research UK)博士后及Research Fellow
2009-至今:   浙江大学医学院基础医学系

研究方向:
从分子生物学、毒理和药理学方面研究环境污染物致癌机理,并为有效地预防癌变提出新方法和研发新药物。

代表性论文:
1. Wang XJ, Chamberlain M, Vassieva O, Henderson CJ and Wolf CR (2005) Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Biochem J, 388: 857-867
2. Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR (2007) Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Research 67 (19): 9289-57
3. Wang XJ, Hayes JD, Higgins LD, Wolf CR and Dinkova-Kostova AT (2010) Activation of the nrf2 signalling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones. Chemistry & Biology 17: 75-85
4. Wang XJ, Hayes JD, Henderson CJ and Wolf CR (2007) Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc. Natl. Acad. Sci. USA, 104(49): 19589-94
5. Wright MC, Wang XJ, Pimenta M, Ribeiro V, Paine AJ, Lechner MC (1996) Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid. Mol Pharmacol. 50(4):856-63.
6. Xiuwen Tang*, Hongyan Wang, Longfang Fan, Xiaoyuan Wu, Ai Xin, Huanyu Ren and Xiu Jun Wang* (2011) Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs Free Radical Biology and Medicine 50(11),1599-1609 (IF: 6.08)
7. 王秀君 吴加国 唐修文* Nrf2-ARE通路抑制作用研究展望 浙江大学学报(医学版)2010;39(1):1-5