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基本信息:

姓名: 陈莹莹
职务:
职称: 副教授
学历: 博士
专业: 病理生理学
所属院系: 基础医学系
研究方向: 心脏移植的临床前研究;脓毒症心血管损伤机制和治疗的研究
电话: 0571-88208250
信箱: bchenyy@zju.edu.cn
个人主页:

个人简介:

简历
1999-2002 浙江大学医学院生理学,博士研究生
2003-2009 浙江大学医学院生理学,副教授
2009-至今 浙江大学医学院病理生理学,副教授
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科研资助

1. 线粒体乙醛脱氢酶2对脓毒症心肌的保护作用及其机制研究,国家自然科学基金项目(81272067),2013.1-2016.12
2. 葡萄糖加重脂多糖诱导的血管内皮炎症反应及其机制研究,浙江省自然科学基金项目(Y2100082),2011.1-2013.12
3. 葛根素对糖尿病血管内皮内质网应激的作用及机制研究 浙江省教育厅科研项目(Y200908945),2009.12-2011.12
4. 环氧化酶2抑制剂对抗心肌氧化应激的机制研究 国家自然科学基金项目(30400094)2005.1-2007.12
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发表的主要论文

1. Xu HJ, Chen WL, Wang Y, Zheng MZ, Chen YY, Shen YL. S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 2012, 31(6):663-669
2. Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol 2012, 26(3):322-331
3. Yang F, Chen WL, Zheng MZ, Yu GW, Xu HJ, Shen YL, Chen YY. Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of bid in hypothermic preservation rat hearts. J Heart Lung Transplant 2011; 30(8): 928-34
4. Chen YY, Zheng MZ, Lv PP, Hu L, Wang LL, Shen YL. Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism. J Biochem Mol Toxicol 2010;24(5):279-285.
5. Meng XH, Ni C, Zhu L, Shen YL, Wang LL, Chen YY. Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta. Vascul Pharmacol. 2009, 50(3-4): 110-115.
6. Fang XD, Yang F, Zhu L, Shen YL,Wang LL, Chen YY. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clinical and Experimental Pharmacology and Physiology. 2009, 36(12): 1177-1182.
7. 郑鸣之,范莹,孟香红,朱立,沈岳良,陈莹莹. 高糖通过环氧化酶2依赖性途径诱导GRP78表达改变. 中国病理生理杂志 2009, 25(8): 1576-1580.
8. Yan ZK, Hu ZB, Pan XH, Chen YY, Zhang XM, Shen YL. Diazoxide supplemented Celsior solution improves hypothermic heart preservation effect in rat through activation of mitochondrial ATP-sensitive potassium channel. Pharmaceutical Biology. 2009, 47(11): 1060-1066.
9. 范莹,郑鸣之,郭炜,蒋建平,朱立,沈岳良,陈莹莹。二氮嗪对大鼠心脏长时程冷保存时Fas/FasL蛋白表达的影响。生理学报。2008,60(1):11-16
10. 吕萍萍,朱立,郦阳明,陈莹莹,沈岳良。缺血后处理对抗大鼠离体心脏缺血再灌注损伤及其作用机制。中国病理生理杂志。2008,24(5):849-851
11. Chen N, Shao W, Lv PP, Zhang SL, Chen YY, Zhu L, Lu Y, Shen YL. Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells. Free Radical Research. 2007, 41(9):990-6
12. Lv PP, Fan Y, Chen WL, Shen YL, Zhu L, Wang LL, Chen YY. COX-2 inhibitor nimesulide protects rat heart against oxidative stress by improving endothelial function and enhancing NO. Sheng Li Xue Bao. 2007, 59(5):674-680
13. Guo W, Chen N, Chen YY,, Xia Q, Shen YL. Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30.
14. Shen YL, Chen YY, Wu XD, Bruce IC, Xia Q. Activation of Mitochondrial ATP-Sensitive Potassium Channels Delays Ischemia-Induced Cellular Uncoupling in Rat Heart. Acta Pharmacologica Sinica, 2004, 25(1):22-28
15. Ke Y, Chen YY, Chang YZ, Duan XL, Ho KP, Jiang de H, Wang K, Qian ZM. Post-transcriptional expression of DMT1 in the heart of rat. J Cell Physiol. 2003, 196(1):124-30.
16. Chen YY, Ho KP, Xia Q, Qian ZM. Hydrogen peoxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats. Mol Cell Biochem, 2002, 231(1-2): 61-68.