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基本信息:

姓名: 沈岳良
职务: PI
职称: 教授
学历: 本科
专业: 病理生理学
所属院系: 基础医学系
研究方向: 心脏移植的临床前研究
电话: 0571-88208250
信箱: shenyueliang@gmail.com
个人主页:

个人简介:

浙江大学医学院病理生理学教授,硕士生导师。1984年毕业于浙江医科大学医学系。浙江生理学会理事,中国老年学学会理事。1998年获国家教育部霍英东教育基金会青年教师三等奖,1998年荣获浙江省高校优秀青年教师称号。主持过七个课题的工作,参加多个课题组的工作。主要从事心血管病理生理学和药理学研究和计算机技术在病理生理学中的应用。已发表论文40余篇。
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科研资助

1) 线粒体解偶联蛋白2介导心脏低温保存损伤及其机制研究,国家自然科学基金项目(81270178),2013.1-2016.12
2) Cx43线粒体转位对低温保存心脏的保护作用和分子机制研究,国家自然科学基金项目2011.1-2013.12
3) 护理人员知识管理软件的开发和实施 企事业单位委托科技项目(H20092887)2009.10-2010.12
4) 护理管理软件的开发和实施, 企事业单位委托科技项目(H20081813) 2008.08-2009.12
5) 线粒体ATP敏感性钾通道在心脏超时低温保存中的作用 国家自然科学基金项目 2005.1-2007.12
6) 临床前毒理学实验系统平台建设 863项目子课题 2003.1-2005.12
7) 缝隙连接在缺血心肌保护中的作用及其机制 省自然科学基金项目 1999-2001
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发表的主要论文

1) Xu HJ, Chen WL, Wang Y, Zheng MZ, Chen YY, Shen YL. S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 2012, 31(6):663-669
2) Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol 2012, 26(3):322-331
3) Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol 2012, 26(3):322-331
4) Zhang XW, Li WF, Li WW, Ren KH, Fan CM, Chen YY, Shen YL. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm Biol 2011;49(3):256-61
5) Chen YY, Zheng MZ, Lv PP, Hu L, Wang LL, Shen YL. Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism. J Biochem Mol Toxicol 2010;24(5):279-285.
6) Yan ZK, Hu ZB, Pan XH, Chen YY, Zhang XM, Shen YL. Diazoxide supplemented Celsior solution improves hypothermic heart preservation effect in rat through activation of mitochondrial ATP-sensitive potassium channel. Pharmaceutical Biology. 2009, 47(11): 1060-1066.
7) Wu PL, Lin GH, Kang XD, Yuan H, Shen YL. Complement activation by carotenoid derived aldehydes in cultured human vein epithelial cells. Phytother Res 2009, 23(12): 1696-1700.
8) 郑鸣之, 蒋建平, 陈文良, 张小兵, 朱立, 沈岳良, 陈莹莹. 二氮嗪对冷保存诱导的大鼠供心Smac/DIABLO蛋白表达的抑制作用. 中国病理生理杂志 2009, 25(9): 1676-1680.
9) Ma J, Zheng M, Shen Y, Wang L, Wang L, Zhu Y, Zhang X. Effects of cilostazol on thrombospondin-1 (TSP-1) expression changes in the myocardium of diabetic rats. J Int Med Res 2008;36(4):800-809.
10) Yang M, Xu Z, Zhang R, Zhang P, Weng Y, Shen Y, Zhang X. Protection of myocardium in streptozotocin-induced diabetic rats by water extracts of Hsian-tsao (Mesona procumbens Hemsl.). Asia Pac J Clin Nutr. 2008;17(1):23-9.
11) Zhang XG, Yan H, Shen YL, Zhang XM. Decreased thrombospondin-I (TSP-I) expression in the hippocampus of streptozotocin-induced diabetic rats. Exp Clin Endocrinol Diabetes. 2008 Jun;116(6):309-14.
12) 范莹,郑鸣之,郭炜,蒋建平,朱立,沈岳良,陈莹莹。二氮嗪对大鼠心脏长时程冷保存时Fas/FasL蛋白表达的影响。生理学报。2008,60(1):11-16
13) 吕萍萍,朱立,郦阳明,陈莹莹,沈岳良。缺血后处理对抗大鼠离体心脏缺血再灌注损伤及其作用机制。中国病理生理杂志。2008,24(5):849-851
14) 郑鸣之,蒋建平,陈莹莹,朱立,沈岳良,郑良荣。缺血后处理对不同时程冷保存大鼠心脏的作用研究。浙江大学学报(医学版)。2007,36(6):567-574
15) Chen N, Shao W, Lv PP, Zhang SL, Chen YY, Zhu L, Lu Y, Shen YL. Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells. Free Radical Research. 2007, 41(9):990-6(SCI收录, IF=2.536)
16) 汪洋,杜友爱,徐和靖,郭炜,陈莹莹,沈岳良。HO-1在保护缺氧-复氧心脏中的作用及其机制研究。中国病理生理杂志。2006;22(6);1087-1091
17) Guo W, Chen N, Chen YY, Xia Q, Shen YL. Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30
18) Shen YL, Chen YY, Wu XD, Bruce IC, Xia Q. Activation of Mitochondrial ATP-Sensitive Potassium Channels Delays Ischemia-Induced Cellular Uncoupling in Rat Heart. Acta Pharmacol Sin. 2004, 25(1):22-28
19) Cao CM, Xia Q, Chen YY, Zhang X, Shen YL. Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat. Pflugers Arch, 2002, 443(4): 635-42.
20) Wu XD, Shen YL, Cao CM, Xu WH, Xia Q. A model of gap junction conductance and ventricular tachyarrhythmia.Proceedings of 23rd Annual international conference of the IEEE engineering in medicine and biology society. 2001