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基本信息:

姓名: 周天华
职务: 主任
职称: 教授
学历: 博士
专业: 细胞生物学、病理学与病理生理学
所属院系: 基础医学系
研究方向: 分子细胞生物学、胃肠肿瘤学
电话: 0571-88208009
信箱: tzhou@zju.edu.cn
个人主页: http://mypage.zju.edu.cn/0005005

个人简介:

周天华,博士,浙江大学求是特聘教授,“国家杰出青年科研基金”获得者,国家“万人计划”科技领军人才,教育部“新世纪优秀人才计划”获得者、科技部“中青年科技创新领军人才”,浙江省“钱江人才计划”获得者,浙江省重点科技创新团队(胃肠疾病诊治新技术创新团队)首席科学家;兼任中国细胞生物学学会理事、中国细胞生物学学会青年委员会副主任委员、细胞结构与细胞行为分会副会长、浙江大学青年教授联谊会副会长、Cell Research(影响因子14.8)、Journal of Experimental Clinical Cancer Research(影响因子4.8)等期刊编委。1988年起就读于浙江大学医学院,1993年获医学学士学位,1996年获临床医学硕士学位,1999年毕业于中科院上海生命科学研究院获博士学位。2000年至2006年在美国哈佛大学分子细胞生物学系进行博士后训练。现任浙江大学学位评定委员会办公室主任、学科建设处处长、医学院细胞生物学与遗传学系主任、分子医学研究中心主任、医学细胞生物学主讲教师(http://mypage.zju.edu.cn/0005005)。


周天华博士在分子细胞生物学和分子肿瘤学领域具有比较扎实的理论知识和实践基础,长期从事细胞运动与细胞周期的分子调控及其在癌症发生发展中作用的研究,在细胞核分布基因C(NudC)通路的分子调控领域中取得了突破性进展。自1998年以来,已在《Dev Cell》(Cell 子刊)、《PNAS》(美国国家科学院院刊)和《J Biol Chem》等国际学术期刊发表了40篇原始学术论文,合计影响因子超过290,受到国际同行们的关注(他引超过1000多次)。国际权威杂志Nature Reviews Molecular Cell Biology曾经以新闻的方式报道过其工作,由世界知名生物医学科学家组成的独立同行评议服务机构Faculty of 1000,也专门推荐其研究成果。2009年起,其领导的研究小组在细胞运动分子机理调控及癌症发生发展的细胞运动基础等领域,取得了一些有价值的实验结果,在《Cell Research》、《PNAS》和《J Biol Chem》等国际著名刊物上发表了一系列的原创性学术文章。近年来,作为负责人担任国家杰出青年科学基金1项、国家自然科学基金国际合作重点项目1 项、重点重大项目子课题1项、面上项目5项、973计划项目课题和子课题各1项及其他多个项目,累计资助经费超过2000万。获浙江省科技进步一等奖一项、中华医学科技奖三等奖一项、浙江省医药卫生科技创新奖一等奖一项、美国专利一项、中国专利一项(排名均在前三)。入选浙江省“卫生高层次创新人才计划”、浙江省“钱江人才计划”、 浙江省“151人才计划”(第一层次)等。

实验室网站:http://www.cmm.zju.edu.cn/molecule/GroupServe234.aspx
课程网站:http://10.71.121.158/G2S/Template/View.aspx?action=view&courseType=1&courseId=27337&ZZWLOOKINGFOR=G)。

主要学术兼职:
Cell Research (最新影响因子10.5)编委
中国细胞生物学学会理事
中国细胞生物学学会青年委员会副主任委员
中国细胞生物学学会细胞结构与功能分会副会长
浙江大学青年教授联谊会副会长

近年来发表主要SCI论文:
作为通讯作者和第一作者的主要论文(* 通讯作者):
1. Shen M, Cai Y, Yang Y, Yan X, Liu X and Zhou T*. (2013). Centrosomal Protein FOR20 is essential for S-phase progression by Recruiting Plk1 to Centrosomes. Cell Research 23(11):1284-1295. doi:10.1038/cr.2013.127(最新影响因子: 10.526)published online 10 September 2013.
2. Deng Y, Huang Z, Xu Y, Jin J, Zhuo W, Zhang C, Zhang X, Shen M, Yan X, Wang L, Wang X, Kang Y, Si J* and Zhou T*. (2013). MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Letters  Aug 24. doi: 10.1016/j.canlet.2013.08.033. (最新影响因子: 4.23).
3. Liu Y, Yan X and Zhou T*. (2013). TBCK Influences Cell Proliferation, Cell Size and mTOR Signaling Pathway. PLOS ONE 8(8): e71349. doi:10.1371/journal.pone.0071349 (最新影响因子3.73).
4. Xu Y, Deng Y, Yan X and Zhou T*. (2011). Targeting miR-375 in gastric cancer. Expert Opinion on Therapeutic Targets 15(8):961-972.(当年影响因子: 3.716)
5. Zhu X, Liu X, Jin Q, Cai Y, Yang Y and Zhou T*. (2010). The L279P Mutation of Nuclear Distribution Gene C (NudC) Influences Its Chaperone Activity and LIS1 Stability. Journal of Biological Chemistry 285(39):29903-29910. (当年影响因子: 5. 328)
6. Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Hao H, Liu X, Si J* and Zhou T*. (2010). MiR-375 Frequently Down-regulated in Gastric Cancer Inhibits Cell Proliferation by Targeting JAK2. Cell Research 20(7):784-793. (当年影响因子: 9.417)
7. Yang Y, Yan X, Cai Y, Lu Y, Si J and Zhou T*. (2010). NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proceedings of the National Academy of Sciences of the United States of America 107(8): 3499-3504.(当年影响因子: 9.771)
8. Cai Y, Yang Y, Shen M and Zhou T*. (2009) Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody. Cell Research 19(11):1305-1308. (当年影响因子: 8.151)
9. Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T* and Si M*. (2009) Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. Journal of Gastroenterology 44(6):556–561. (当年影响因子: 2.909)
10. Zhou T, Zimmerman W, Liu X and Erikson RL. (2006). A Mammalian NudC-Like Protein Essential for Dynein Stability and Cell Viability. Proceedings of the National Academy of Sciences of the United States of America  103(24):9039-9044. (当年影响因子: 9.643)
11. Zhou T,* Aumais J, Liu X, Yu-Lee, LY and Erikson, RL. (2003). A role for Plk1 phosphorylation of NudC in cytokinesis. Developmental Cell 5(1):127-138. (当年影响因子: 14.807)
12. Zhou TH, Ling K, Guo J, Zhou H, Wu Y, Jing Q, Ma L and Pei G. (2000). Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. Journal of Biological Chemistry 275(4):2513-2519. (当年影响因子: 7.368))
13. Wu GX,# Lin YM, # Zhou TH, # Gao H and Pei G. (2000). Significant down-regulation of alpha-albumin in human hepatoma and its implication. Cancer Letters 160(2), 229-236. (#共同第1作者,当年影响因子: 1.517)
14. Zhou TH, Ren XH, Yin DL, Wu YL, Li M, Lu CZ, Wu DC, Wu YQ, Peng YQ, Wang YP, Ma L and Pei G. (1997). Retardation of pain development: a case of recovery from congenital insensitivity to pain. Acta Anaesthesiologica Scandinavica 41, 1077-1079. (当年影响因子: 1.953)


作为合作作者的主要论文:
15. Shao CY, Zhu J, Xie YJ, Wang Z, Wang YN, Wang Y, Su LD, Zhou L, Zhou TH and Shen Y. (2013). Distinct Functions of Nuclear Distribution Proteins LIS1, Ndel1 and NudCL in Regulating Axonal Mitochondrial Transport. Traffic 14:785-797.(最新影响因子: 4.919)
16. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Jin H and Si J. (2012). Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Molecular Medicine 18(3):389-400(最新影响因子: 3.757)
17. Yin Y, Li J, Chen S, Zhou T and Si J. (2012). MicroRNAs as Diagnostic Biomarkers in Gastric Cancer. Int J Mol Sci. 13(10):12544-12555. (最新影响因子: 2.598)
18. Gan L, Chen S, Zhong J, Wang X, EK Lam, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L, and Jin H. (2011). ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PloS One  6(2): e16916. (当年影响因子: 4.092)
19. Zhou Q, Lu X, Gan L, Chen S, Zhou T, Wang L and Si J. (2010). Role of REG Iα in gastric carcinogenesis: Gastrin-associated proliferative and anti-apoptotic activities. Molecular Medicine REPORORTS  3(6): 999-1005. (当年影响因子: 0.307)
20. Li A, Zhou T, Guo L, Si J. (2010) Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells. Oncology Reports 23(5):1247-1255. (当年影响因子: 1.686)
21. Zhao Y, Zhou T, Yao H, Hei F, Wang L and Si J. (2009) A Potential Role of Collagens Expression in Distinguishing between Premalignant and Malignant Lesions in Stomach. The Anatomical Record 292(5):692-700. (当年影响因子: 1.490)
22. Chen Y, Chen Y, Liu WL, Zhou TH, Cai JT, Du Q, Wang LJ, Wu JG and Si JM. (2009). Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. Journal Gastroenterology and Hepatology 24(5):912-919. (当年影响因子: 2.317)
23.Pan H, Sheng JZ, Tang L, Zhu R, Zhou TH and Huang HF. (2008). Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients. Fertility & Sterility 90(4):1000-1007.(当年影响因子: 4.167)
24. Li M, Zhou TH, Gao Y, Zhang N and Li JC. (2007). Ultrastructure and estrogen regulation of the lymphatic stomata of ovarian bursa in mice. The Anatomical Record 290(10):1195-1202. (当年影响因子: 1.800)
25. Liu WL, Chen SJ, Chen Y, Sun LM, Zhang W, Zeng YM, Zhou TH and Si JM. (2007). Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. Acta Pharmacology Sinica 28(7):1001-1006. (当年影响因子:1.67)
26. Liu AX, Jin F, Zhang WW, Zhou TH, Zhou CY, Yao WM, Qian YL and Huang HF. (2006). Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. Biology of Reproduction 75(3):414-420. (当年影响因子:3.498)
27. Liu X, Lin CY, Lei M, Yan S, Zhou T and Erikson RL. (2005). CCT chaperonin complex is required for the biogenesis of functional Plk1. Molecular and Cellular Biology 25(12):4993-5010.(当年影响因子: 7.093)
28. Liu X, Zhou T, Yan S and Erikson RL. (2004). Molecular interaction of polo-like kinase 1 with mitotic kinesin-like protein CHO1/MKLP-1. Journal of Cell Science 117(15):3233-3246. (当年影响因子: 6.910)
29. Liu X, Yan S, Zhou T, Terada Y and Erikson RL. (2004). The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23(3): 763-776. (当年影响因子: 6.318)
30. Wang P, Wu Y, Zhou TH, Sun Y and Pei G. (2000). Identification of alternative splicing variants of the beta subunit of human Ca (2+)/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475(2):107-110. (当年影响因子: 3.440)
31. Yu QM, Cheng ZJ, Zhou TH, Cen B, Guo SQ and Pei G. (1999). Molecular cloning of human beta arrestin1 cDNA, expression and function study. Acta Biochimica et Biophysica Sinica 31(3):344-346. (最新影响因子:1.807)
32. Lou LG, Zhou T, Wang P and Pei G. (1999). Modulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of  and  Isoforms. Molecular Pharmacology 55(3):557-563. (最新影响因子: 4.411)
33. Yu QM., Cheng ZJ, Zhao J, Zhou TH, Wu YL Ma L and Pei G. (1998). Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin. Cell Research 8(4),:303-310. (最新影响因子: 10.526)
34. Fan GH, Zhou TH, Zhang WB and Pei G. (1998). Suppression of Phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity. European Journal of Pharmacology 341(2), 317-322. (最新影响因子: 2.592)
35. Wu Y L, Fan GH, ZhaoJ, Zhou TH, Ma L and Pei, G. (1997). Functional expression of Opioid receptor-like Receptor and its endogenous specific agonist Nociceptin/Orphanin FQ during Mouse embryogenesis. Cell Research 7(2):207-215. (最新影响因子: 10.526)

英文著作:
1. Zhou, T. and Erikson, R.L. A role of Polo-like kinase 1 phosphorylation of NudC in cytokinesis. In Signal Transduction of Cell Division, T. Miki, ed. (Research Signpost). (2005).

在美国基因数据库(GenBank)登录的基因:
FJ215684 (Homo sapiens NudC-like protein 2),
AF083420 (homo sapiens brain-specific STE20-like protein kinase 3, MST3b),
AF078803 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta subunit),
AF081924 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta 6 subunit),
AF140350 (Homo sapiens calcium/calmodulin-dependent protein kinase II beta 7 subunit),
AF083419 (homo sapiens calcium/calmodulin-dependent protein kinase beta 2 e subunit),
AF081572 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta e’ subunit),
AF091486 (homo sapiens calcium/calmodulin-dependent protein kinase 2 alpha subunit),
AF084040 (homo sapiens beta-arrestin 1A),
AF084940 (homo sapiens beta-arrestin 1B),
AF106941 (homo sapiens beta-arrestin 2).

相关获奖成果:
1、胃癌前病变癌变准确监测和有效阻断技术体系的建立(2012年浙江省科技进步一等奖,排名第3/11)
2、胃癌前病变癌变准确监测和有效阻断技术体系的建立(2009年浙江省医药卫生科技创新一等奖、排名第3/11)
3、胃癌前病变癌变准确监测和有效阻断技术体系的建立(2009年中华医学科技三等奖、排名第3/11)
4、浙江省第六届青年教师教学技能比赛优秀奖(2011年,浙江省青年教师大会特邀报告)
5、浙江大学青年教师教学技能比赛一等奖

相关专利:
1. 美国专利“Method for detecting liver cell in peripheral blood” (专利证书号:CN1331417-A,排名第三)
2. 中国专利:一种检测用生物标志物及应用(专利证书号:ZL200810163151.3,排名第二)