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基本信息:

姓名: 胡虎
职务: PI
职称: 教授
学历: 博士
专业: 病理与病理生理学
所属院系: 基础医学系
研究方向: 血小板基础研究
电话: 0571-88208715
信箱: huhu@zju.edu.cn
个人主页:

个人简介:

教育工作背景:
1996年7月 浙江医科大学                            本科
2003年12月 瑞典卡罗琳斯卡研究院临床药理系         博士
2004-2005 年 比利时鲁汶大学分子血管中心         博士后
2005-2010  浙江大学医学院(人才引进)   副教授,副博士生导师
2011-       浙江大学医学院               教授,博士生导师

学术及社会兼职:
国际血栓与凝血协会(ISTH)会员
浙江省“151人才工程”培养人员
Thrombosis Journal杂志编委
主要学术成绩:
在瑞典Karolinska Institute获得博士学位,其后在世界知名的血管生物和凝血研究中心-比利时鲁汶大学分子血管生物中心接受博士后训练,长期致力于代谢性疾病中的血栓和炎症相互作用,细胞内信号转导,和抗血栓药物药理学研究。对血栓和炎症过程中由细胞间黏附分子介导的细胞间相互作用,血栓细胞的分子信号转导,流式细胞术检测,已及抗血栓先导药物的功能和分子靶点鉴定方面做了大量的工作。共发表SCI收录论文20多篇,包括ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (影响因子6.86),Journal of Thrombosis and Haemostasis (影响因子6.07),DIABETOLOGIA(影响因子6.42)等杂志,累计杂志影响因子90,他引234次。回国后建立的研究团队已发表SCI收录论文7篇,其中抗血栓先导药物的功能和分子靶点鉴定工作结果发表于血栓研究领域的国际高影响因子期刊Journal of Thrombosis and Haemostasis (影响因子6.07)。目前主持国家自然基金2项,共同主持瑞典国家自然科学基金项目1项,主持教育部,人事部课题各一项,作为骨干参与国家支撑项目1项,完成浙江省自然科学基金1项。2006年获亚太血栓和凝血年会青年研究者奖, 2009年获国际血栓凝血年会旅行奖。
主要科研项目:
1.血小板P2X1受体通过激活MAP激酶p38的新信号转导机制研究(项目负责人), 国家自然科学基金,17万,2008.1-2010.12,在研,项目编号30700267
2.胞膜微区结构脂筏和Tetraspanin富集区域调控癌细胞-血小板粘附的机制研究 (项目负责人),  国家自然科学基金,8万,2010.1-2010.12,在研,项目编号30970656  
3.血小板淋巴细胞相互作用在动脉粥样硬化中的意义 (项目共同负责人),
 瑞典国家自然科学基金,60万,2008.1-2010.12,在研
4.“十一五”国家科技支撑计划项目“代谢综合征的早期识别和干预技术研究”(骨干),科技部,3200万,2009-2012,在研
5.2型糖尿病白细胞-血小板相互作用机制(项目负责人),浙江省自然科学基金,7 万元, 2007.1-2009.12,结题,项目编号Y206095
6.2型糖尿病白细胞-血小板相互作用机制及临床治疗关系(项目负责人),人事部归国留学人员择优资助项目 3万元,2007.1-2009.12, 在研。
7.脂阀与血小板P2X1受体信号转导通路研究(项目负责人),教育部归国留学人员 启动基金,3万元,在研,项目编号20071108 发表论文:
1. Hu H(胡虎), Daleskog M, Li N. Influences of fixatives on flow cytometric measurements of platelet P-selectin expression and fibrinogen binding. Thromb Res 2000; 100: 161-166.(影响因子2.01)
2. Li N, Hu H(胡虎), Linqvist M, Wikström Jonsson E, Goodall AH, Hjemdahl P. Platelet-leukocyte cross-talk in whole blood. Arterioscler Thromb Vasc Biol. 2000; 20: 2702-2708. (影响因子7.05)
3. Hu H(胡虎), Li N, Ekberg K, Johansson BL, Hjemdahl P. Insulin, but not proinsulin C-peptide, enhances platelet fibrinogen binding in vitro in Type 1 diabetes mellitus patients and healthy subjects. Thromb Res. 2002, 106:91-5. (影响因子2.01)
4. Hu H(胡虎), Hjemdahl P, Li N. Effects of insulin on platelet and leukocyte activity in whole blood. Thromb Res. 2002, 107:209-15. (影响因子2.01)
5. Hu H(胡虎), Zhang W, Li N. Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. J Thromb Haemost 2003, 2:1-8. (影响因子5.26)
6. Hu H(胡虎), Varon D, Hjemdahl P, Savion N, Schulman S, Li N. Platelet-leukocyte aggregation under shear stress: Differential involvement of selectins and integrins. Thromb Haemost 2003, 90: 679-87. (影响因子3.06)
7. Li N, Hu H(胡虎), Hjemdahl P. Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res. 2003;111:165-70. (影响因子2.01)
8. Hu H(胡虎), Li N, Yngen M, Österson C-G, Wallen NH, Hjemdahl P. Enhanced leukocyte-platelet cross-talk in type 1 diabetes mellitus: relationship to microangiopathy. J Thromb Haemost. 2004, 2: 58-64. (影响因子5.26)
9. Yngen M, Ostenson CG, Hu H(胡虎), Li N, Hjemdahl P, Wallen NH. Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation. Diabetologia. 2004, 47:537-40. (影响因子5.34)
10. Hu H(胡虎), Johansson B, Hjemdahl P, Li N. Exercise-induced platelet and leucocyte activation is not enhanced in well-controlled Type 1 diabetes, despite increased activity at rest. Diabetologia. 2004, 47:853-9. (影响因子5.34)
11. Perneby C, Wallen NH, Hu H(胡虎), Li N, Hjemdahl P. Prothrombotic responses to exercise are little influenced by clopidogrel treatment. Thromb Res. 2004, 114:235-43. (影响因子2.01)
12. Hu H(胡虎), Forslund M, Li N. Influence of extracellular calcium on single platelet activation as measured by whole blood flow cytometry. Thromb Res. 2005, 116:241-7. (影响因子2.01)
13. Oury C, Daenens K, Hu H(胡虎), Bryckaert M, Hoylaerts MF. ERK2 activation in arteriolar and venular murine thrombosis: role of platelet receptors GPIb and P2X1. J Thromb Haemost. 2006, 4(2):443-52. (影响因子5.26)
14.Dong Z, Hu H(胡虎),Chen W, Li z, Liu G, Yang J. Heat shock does not induce ΓH2AX foci formation but protects cells from N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity. Mutation Research. 2007, 629:40-8. (影响因子2.18)
15. Razmara M, Hu H(胡虎), Masquelier M, Li N. Glycoprotein IIb/IIIa blockade inhibits platelet aminophospholipid exposure by potentiating translocase and attenuating scramblase activity. Cell Mol Life Sci. 2007,64:999-1008. (影响因子4.65)
16.Xu F, Wang F, Di M, Huang Q, Wang M, Hu H(胡虎), Jin Y, Dong J, Lai M. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res. 2007, 13:5082-8。(影响因子6.18)
17.Ruan W, Xu E, Xu F, Ma Y, Deng H, Huang Q, Lv B, Hu H(胡虎), Lin J, Cui J, Di M, Dong J, Lai M. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer Biol Ther. 2007,6:354-9. (影响因子2.71)
18.Ruan WJ, Lin J, Xu EP, Xu FY, Ma Y, Deng H, Huang Q, Lv BJ, Hu H(胡虎), Cui J, Di MJ, Dong JK, Lai MD. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. Zhejiang Univ Sci B. 2006,7:929-32.
19. Ma Y, Lu B, Ruan W, Wang H, Lin J, Hu H(胡虎), Deng H, Huang Q, Lai M. Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. Exp Mol Pathol. 2008, 85:141-5. ( 影响因子2.05)
20. Zou XH, Cai HX, Yin Z, Chen X, Jiang YZ, Hu H(胡虎), Ouyang HW. A novel strategy incorporated the power of mesenchymal stem cells to allografts for segmental bone tissue engineering. Cell Transplant. 2009, 18:433-41. (co-corresponding author) ( 影响因子5.13)
21. Chen X, Song XH, Yin Z, Zou XH, Wang LL, Hu H(胡虎), Cao T, Zheng M, Ouyang HW. Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors. Stem Cells. 2009, 27:1276-87. ( 影响因子7.75)
22. Xu F, Xu J, Lou Z, Di M, Wang F, Hu H(胡虎), Lai M. Micropapillary Component in Colorectal Carcinoma is Associated With Lymph Node Metastasis in T1 and T2 Stages and Decreased Survival Time in TNM Stages I and II. Am J Surg Pathol. 2009, 33:1287-92. ( 影响因子4.06)
23. Hu H(胡虎), Hoylaerts MF. The P2X1 ion channel in platelet function. Platelets 2010, 21:153-66. ( 影响因子2.27)
24. Huang ZS, Zeng C, Zhu L, Jiang L, Li N, Hu H(胡虎). Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of PI3K. J Thromb Haemost. 2010, 8:1383-93.( 影响因子6.07) (corresponding author)
25.Hu XS, Du C, Zeng CL, Yao L, Zhang F, Wang K, Chen J, Li N, Hu H(胡虎). Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension. Cardiology 2010, 117(1):44-53. ( 影响因子1.64) (corresponding author)
26. Hu H(胡虎), Zhu L, Huang ZS, Ji Q, Chatterjee M, Zhang W, Li N. Platelets selectively enhance lymphocyte adhesion and infiltration into arterial thrombus. Thromb Haemost. 2010, 104(6):1184-926. ( 影响因子4.46)