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基本信息:

姓名: 吴息凤
职务: 公共卫生系主任;浙江大学医学院附属第二医院副院长;浙江大学健康医疗大数据国家研究院院长
职称: 教授
学历: 博士
专业: 1.分子流行病学,2.肿瘤流行病学
所属院系: 公共卫生系
研究方向: 肿瘤分子流行病学, 健康医疗大数据,生物标志物, 精准医学, 风险预测人工智能
电话:
信箱: xifengw@zju.edu.cn
个人主页: https://person.zju.edu.cn/0019030

个人简介:

1984年获复旦大学(原上海第一医学院)医学学位,1987年获浙江大学(原浙江医科大学)硕士学位,1991年在法国获得博士后,1994年从德州大学公共卫生学院获得博士学位。1995年起至2019年任职于美国癌症医院历年排名第一的德州大学MD安德森癌症中心,兼任德克萨斯大学公共卫生学院流行病学教授。2004年开始授予终身教授,2006年开始授予Ashbel Smith Professorship冠名教授,2008年起至2019获得癌症预防Betty B. Marcus冠名主席,2010年起至2019担任癌前基因组图谱计划主任,转化医学和公众健康基因组学中心主任包括血液样本库和个体化风险预测项目,2011年起至2019担任病史数据库主任。2011年起至2015担任流行病学系系主任和流行病学学科负责人。

作为一名拥有多学科知识背景和创新理念的科学家,吴教授使用高度创新,循证医学,和整合的战略建立一系列的大数据,大型样本库,发现和验证可改变肿瘤危险因素,筛选癌症药物遗传生物标志物,利用高端的生物信息和生物统计方法建立整合性的风险预测模型并转成一系列的基于互联网的个人预测模型的人工智能工具,建立高危人群早期识别方法,为制定有针对性个体化的精准肿瘤预防和治疗领域做出了卓越的贡献,她领导的团队成为该领域的世界顶尖团队之一。

吴教授的团队建立了一系列大型的样本库、数据库、队列和风险预测模型,包括:1) MD安德森癌症中心病史资料库:系统地收集在MD安德森癌症中心进行治疗的肿瘤患者的流行病学和临床数据,并成功实现了采集过程的电子化。到目前为止,已经收集了超过55万例患者的资料;2) MD 安德森癌症中心肿瘤患者血液标本研究资源库:采集所有在MD安德森癌症中心新登记的肿瘤患者的血液样本,并进行处理和存储。到目前为止,已经收集了11万多名肿瘤患者的DNA、血清和全血标本;3)美兆人群健康筛查队列(MJ Cohort):台湾健康管理机构美兆收集了100余万人的体检资料和详细的基线调查问卷数据,存储了超过10万参与者的血样,与美兆合作,吴教授建立了多个全方位整合肿瘤风险预测模型;4)MD安德森癌症中心癌前病变病人队列:作为MD安德森癌症中心癌前病变基因组图谱项目的负责人,领导建立了癌前病变生物样本库以及相应的研究技术平台,纳入了三种明确的癌前病变,包括结直肠腺瘤、Barrett食管和口腔癌前病变等;5) MD安德森癌症中心肿瘤患者队列(MDA- CPSC):样本库与肿瘤患者血液标本资源库、完善的病史资料库以及先进的实验室相结合,组成了世界一流的肿瘤流行病学和转化医学研究的平台。至今MDA-CPSC队列已经超过20万病例;6) MD安德森癌症中心肿瘤幸存者队列:目前已招募了超过8500例长期存活的肿瘤患者。同时还与儿科合作,收集新诊断的儿童肿瘤病人的血液标本,建立了儿童肿瘤患者生物样本库;7) 世界领先的肿瘤流行病学实验室:集合数据收集中心、标本处理中心、分子流行病学实验室、基因分型检测中心、实验及临床数据管理中心、统计分析中心为一体,是MD 安德森癌症中心最大的实验室之一;8) 美国最大之一的肺癌、膀胱癌、食道癌和肾癌的病例对照研究,以及临床转归流行病研究。吴教授制定了严格的规章制度来利用和管理这些资源,建立了样本和资料使用委员会来评审和批准样本和资料的使用。该委员会已经批准了来自26个部门的130个项目申请,极大地促进了MD安德森癌症中心的科研。以这些平台为依托,吴教授帮助年轻的教授们于2015年获得了4项美国国家癌症研究中心R01基金的资助进行全外显子测序(WES)肿瘤的少见基因变异等课题;三年时间内获得了三千七百万美元的科研基金。这些都充分证明了吴教授的领导才能。

创新的理念和不懈的追求使吴教授的团队一直处于癌症分子流行病研究和分子标志物发现的世界领先地位, 也受到美国国立癌症研究所(NCI)和同行的广泛认可。她一直是MD安德森癌症中心和整个美国癌症流行病领域收到NCI科研基金资助最多的研究者之一。她这20年共获得基金资助总额超过一亿美金,包括16项美国国家癌症研究中心重大项目基金和30项R01基金,充分证明了吴教授团队的研究处于美国和世界领先地位。迄今为止,她已发表论文超过545篇包括自然遗传,柳叶刀,柳叶刀肿瘤学,美国医学会杂志,英国医学期刊,国家癌症研究所杂志,临床肿瘤学杂志,新英格兰医学,自然等全球知名期刊。

她的挑战性研究表明,每天15分钟的适量运动可降低死亡率14%并延长三年的寿命,每多锻炼15分钟就进一步降低4%的总死亡率和1%的癌症死亡率,这导致她提出了MPOWER的措施来减轻不活动导致的健康负担 (Lancet, 2011, 2012, 2013, 2015,IF:53.3)。她发现慢性病导致的超过五分之一的癌症发病和超过三分之一的癌症死亡率风险,这与五大生活方式因素导致的总风险相似。患有慢性疾病风险评分最高的个体的寿命缩短了近16年。认识到这种被忽视的癌症风险可能会改变目前的癌症预防策略并激励更好地控制慢性病。幸运的是,身体活动可能会使与慢性病相关的癌症风险降低近40% (British Medical Journal,2018 IF:28)。她和她的合作团队发现、签定、和证实了多个新的肿瘤遗传易感位点包括肺癌,膀胱癌,肾癌,卵巢癌,睾丸癌和淋巴瘤,(Nature Genetics, 2008, 2009, 2010, 2011, 2012, 2013, and 2014,IF:27.1; Nature Communication, 2015, 2016, 2016, 2017,IF:12.3; Lancet Oncology, 2010 IF:36.4; Cancer Discovery, 2011 IF:24.4;American Journal of Human Genetics 2014;IF:8.86; Clinical Cancer Research 2010, 2017, IF:10.2; Human Molecular Genetics, 2011, 2012, 2013, 2014, 2016,IF:4.9),以及与肺癌患者生存相关的基因位点(Journal of National Cancer Institute, 2011, IF:12.2; Cancer Research, 2013, 2014,IF:9.1)。她利用GWAS发现了一个全新的膀胱癌易感基因PSCA。该项目包括3个美国研究现场,9个欧洲研究现场,以及一个日本研究室。研究发现PSCA基因上的1 个错义突变可导致膀胱癌发病风险增加15%;通过基因重新测序和体外功能学试验,证实该突变与膀胱癌可能存在病因学联系(Nature Genetics,2009 IF: 27.1)。作为主要的研究人员,她利用全基因组关联研究(GWAS)发现人类染色体15q25区域的烟碱乙酰胆碱受体亚单位单核苷酸多态是肺癌易感性位点 (Nature Genetics,2008,IF: 27.1)。她发现了一组在腺瘤和CRC之间具有独特突变模式的基因以及用于早期检测的潜在生物标志物,其可以作为进展的驱动因子。创建了一个20基因突变小组,最佳区分腺瘤和CRC,预测准确度为0.93(Gut,2017, IF:17.0)。 她利用多维数据集成构建了一系列的个体化风险预测模型: 膀胱癌的(Journal of National Cancer Institute,2007, IF:12.2),肝癌(Journal of National Cancer Institute,2012, IF:12.2),肺癌(Scientific Reporter,2016, IF: 4.1),乳腺癌复发(Journal of National Cancer Institute,2017, IF:12.2),辐射毒性(Clinical Pharmacology & Therapeutics,2017, IF: 7.3)和肺癌复发(Clinical Pharmacology & Therapeutics,2017, IF: 7.3 )。

吴教授获得了MD安德森杰出学者奖,德州大学阿什贝尔史密斯冠名教授,玛格丽特和小詹姆斯答:埃尔金斯癌症预防学成就奖,朱莉和本罗杰斯卓越研究奖,贝蒂B. 癌症预防冠名主席,MD安德森研究信托高级研究员,罗伯特·张伯伦杰出导师奖,休斯敦50位最有影响力的女性,以及癌症预防杰出导师奖等多项荣誉。她担任许多美国和国际科研机构的资金评审委员包括美国国家癌症研究所,欧盟研究委员会,英国癌症研究,中国国家分子转化中心, 意大利,波兰,西班牙,新加坡,法国,等许多国家和国际拨款审查。

吴教授担任多名年轻员工、博士生、博士后和临床医生的指导老师。她多次获得最佳团队领导和最佳导师奖。她共培养研究生50名、博士后33名、临床医生和访问学者43人。其中有61人次获得美国癌症研究学会(AACR)青年学者奖等各类学术荣誉和奖励。多名访问学者归国后成为各自单位的骨干力量;她指导和协助流行病学系多位年轻科研人员独立申请并获得National Institute of Health的重大基金资助。她所指导的博士后研究人员成为众多科研机构争选的对象。

 

研究方向 肿瘤分子流行病学, 健康医疗大数据,生物标志物, 精准医学, 风险预测人工智能

 

工作研究项目

担任美国国家健康中心重大项目的主持人或共同主持人

1.     Project Leader, University of Texas LUNG SPORE – Project 2: Epidemiologic Studies of Germline Polymorphisms in miRNA Pathways to Determine Their Role in Risk of Lung Cancer Development and Recurrence, P50 CA070907, NIH/NCI, ~ $1,120,000

2.     Principal Investigator-MDACC, Breast Cancer Genetic Study in African Ancestry Populations, R01 CA202981, Vanderbilt University - NIH/NCI, 7/1/2016-6/30/2021,  ~$60,000

3.     Principal Investigator, Epigenetic miRNA, SNP Signatures, and their Functions in Lung Cancer Outcomes, R01 CA176568, NIH/NCI, 4/1/2014-2/28/2019, ~$1,564,436

4.     Principal Investigator, PQ-A4 Point-of-Care Test of Exposure to Hepatocellular Carcinoma Risk by V-Chip, R01 CA180083, NIH/NCI, 9/10/2013-6/30/2018, ~$2,707,563

5.     Principal Investigator, Molecular Pathways Linking Obesity and RCC Tumorigenesis (PQ1), R01 CA170298, NIH/NCI, 9/1/2012-6/30/2018, ~$2,800,000

6.     Principal Investigator-MDACC, Genetic Epidemiology of non-Hodgkin Lymphoma, R01 CA200703, Mayo Clinic - NIH/NCI, 7/8/2016-5/31/2021, ~$551,630

7.     Principal Investigator, Role of MicroRNA in Lung Cancer Risk & Clinical Outcome Prediction, RP130502, Cancer Prevention & Research Institute of Texas (CPRIT), 6/1/2013-5/30/2017, ~$1,294,346

8.     Principal Investigator-MDACC, Telomere Length and the Risk of Cancer and Diabetes: A Prospective Longitudinal Study, Sister Institution Network Fund, MD Anderson Cancer Center, 11/15/2011-11/14/2013, ~$100,000

9.     Principal Investigator, Prostate SPORE: Project 5. Separating the Chaff from the Wheat: Identifying Patients at Minimal Risk for Prostate Cancer Progression, CA140388-04, NIH/NCI,9/1/2012-8/31/2014,  ~$320,596

10.  Multiple Principal Investigator, Transdisciplinary Research in Cancer of the Lung (TRICL), U19 CA148127, NIH/NCI, 7/9/2010-6/30/2014, ~$4,559,755

11.  Principal Investigator - Project 2, University of Texas SPORE in Lung Cancer. Project 2: Risk Prediction for Platinum-based Chemotherapy and Radiotherapy Outcome in Non-Small Cell Lung Cancer Patients, P50 CA070907, NIH/NCI, 9/1/2009-8/31/2014, ~$1,120,000

12.  Principal Investigator, Lung Cancer Chemoradiation: Predictors of Survival, CA111646-05S1, NIH/NCI, 2009-2010, ~$243,158

13.  Principal Investigator - Project 2, University of Texas SPORE in Head and Neck Cancer, Project 2: Cancer Risk Assessment in Patients with Oral Premalignant Lesions: An Integrative Approach, P50 CA097007, NIH/NCI, 8/1/2008-7/31/2014, ~$1,323,521

14.  Principal Investigator, Genetic Instability and Risk for Esophageal Carcinoma, R01 CA111922, NIH/NCI, 3/10/2008-1/31/2015, ~$2,860,710

15.  Principal Investigator, Genome-Wide Association Analysis of Bladder Cancer, U01 CA127615, NIH/NCI, 4/1/2008-3/31/2015, ~$4,803,014

16.  Principal Investigator: Project 2, GU SPORE Project 2. Markers of Susceptibility as Predictors of Bladder Cancer Recurrence, P50 CA091846, NIH/NCI, 9/25/2006-8/31/2012, ~$1,360,000

17.  Principal Investigator: Project 4, Molecular Epidemiology and Pharmacogenomics in Oral Carcinogenesis, P01 CA106451, NIH/NCI, 8/1/2004-7/31/2009, ~$922,932

18.  Principal Investigator, Genetic Susceptibility to Bladder Cancer, R01 CA074880, NIH/NCI, 2004-2009, ~$1,753,658

19.  Principal Investigator: Project 4, Molecular Epidemiology and Pharmacogenomics in Oral Carcinogenesis, P01 CA106451, NIH/NCI, 8/1/2004-7/31/2009, ~$922,932

20.  Principal Investigator, Genetic Susceptibility Modifiers in Renal Cell Carcinoma, R01 CA098897, NIH/NCI, 8/1/2003-7/31/2008, ~$2,512,529

21.  Principal Investigator,Project 2, GU SPORE, Markers of Susceptibility as Predictors of Bladder Cancer Recurrence, P50 CA091846, NIH/NCI, 9/25/2001-8/31/2006, ~$1,967,363

22.  Project Leader, SPORE in Genitourinary Cancer - Project 2: Role of MicroRNA in Bladder Cancer Risk and Outcome: A Genome-wide Analysis, P50 CA091846, NIH/NCI, 9/25/2001-8/31/2017, ~1,100,000

23.  Principal Investigator, Genetic Influence on Mutagen Sensitivity: A Twin Study, R01 CA085576, NIH/NCI, 5/4/2001-4/30/2005, ~$1,500,000

担任美国国家健康中心重大项目的合作人

1.     Co-Investigator, Next generation sequencing to identify novel colorectal cancer genes, R01 CA177935, NIH/NCI, 6/5/2014-4/30/2019, ~$2,558,150

2.     Co-Investigator, Discovery of Risk Loci and Genomics of Pancreatic Cancer through Exome Sequencing, R01 CA181244, NIH/NCI, 7/11/2014-5/31/2019, ~$4,166,466

3.     Co-Principal Investigator, DNA methylation and telomere length in peripheral blood as predictors of aggressive prostate cancer, RP140556, Cancer Prevention & Research Institute of Texas (CPRIT), 9/1/2014-8/30/2018, ~$853,787

4.     Co-Investigator, High-throughput sequencing to identify novel melanoma susceptibility genes, R01 CA195614, NIH/NCI, 6/1/2015-5/31/2020, ~$3,686,884

5.     Co-Investigator, Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors, R01 CA188943, NIH/NCI, 8/1/2015-7/31/2020, ~$4,821,510

Numerous other grants are not listed here.

 

研究与成果

吴教授使用高度创新,循证医学,和整合的战略的策略来构建一系列的大数据,大型样本库,发现新的行为风险因素,生物标志物,并通过基于证据的人工智能在癌症连续体中创建强大的预测模型,从而为推动精准健康做出了有力的贡献。她拥有出色的资金记录,一直是MD安德森癌症中心和整个美国癌症领域收到美国国家健康中心科研基金资助最多的研究者之一,近年来共承担项目49项 ,其中主持项目30项,主持项目经费共超过4940万美元。20年共获得基金资助总额超过一亿美金。包括16项美国国家癌症研究中心重大项目基金和30项重点(R01)基金。发表论文545余篇, 包括SCI收录论文530余篇。 担任许多美国和国际科研机构的资金评审委员。

 

发表论文 (Selected from over 545 manuscripts and book chapters):

建立一系列的大数据,大型样本库

l  Wu X, Tsai SP, Tsao CK, Chiu ML, Tsai MK, Lu PJ, Lee JH, Chen CH, Wen C, Chang SS, Hsu CY, Wen CP. Cohort Profile: The Taiwan MJ Cohort: half a million Chinese with repeated health surveillance data. Int J Epidemiol. e-Pub 2/2017. PMID: 28204597.

l  Chow WH, Chrisman M, R Daniel C, Ye Y, Gomez H, Dong Q, Anderson CE, Chang S, Strom S, Zhao H, Wu X.. Cohort Profile: The Mexican American Mano a Mano Cohort. Int J Epidemiol. e-pub Mar 8, 2015. PMID: 25747868.

l  Wu X, Hildebrandt MA, Ye Y, Chow WH, Gu J, Cunningham S, Zhao H, Hawk ET, Wagar E, Rodriguez A, Hamilton SR. Cohort Profile: The MD Anderson Cancer Patients and Survivors Cohort (MDA-CPSC). Int J Epidemiol. e-Pub 12/2015. PMID: 26686840.

发现和验证肿瘤相关行为危险因素

l  Tu H, Wen CP, Tsai SP, Chow WH, Wen C, Ye Y, Zhao H, Tsai MK, Huang M, Dinney CP, Tsao CK, Wu X. Cancer risk of chronic diseases and disease markers: a prospective cohort study of 405,878 individuals. British Medical Journal, 360:k134. doi: 10.1136/bmj.k134, 2018 Jan 31, PMID: 29386192.

l  Tu H, Dinney CP, Ye Y, Grossman HB, Lerner S, Wu X. Is folic acid safe? An evidence-based study in non-muscle-invasive bladder cancer patients. Am J Clin Nutr. 107(2):208-216, 2018 Feb 1. PMID: 29529165.

l  Melkonian SC, Daniel CR, Ye Y, Pierzynski JA, Roth JA, Wu X. Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev. 25(3):532-9, 2016. PMID:26944871.

l  Melkonian SC, Daniel CR, Hildebrandt MA, Tannir NM, Ye Y, Chow WH, Wood CG, Wu X. Joint association of genome-Wide association study-identified susceptibility loci and dietary patterns in risk of renal cell carcinoma among non-Hispanic whites. Am J Epidemiol. 180(5): 499-507, 2014 . PMCID: PMC4143080.

l  Shu X, Lin J, Wood CG, Tannir NM, Wu X. Energy Balance, Polymorphisms in the mTOR Pathway, and Renal Cell Carcinoma Risk. J Natl Cancer Inst 105(6):424-32, 3/2013. PMCID: PMC3601952.

l  Wen CP, Tsai MK, Wai JP, Wu X. Promoting increased physical activity and reduced inactivity - Authors' reply. Lancet 381(9861):114-5, 1/2013. PMID: 23312751.

l  Wen CP, Wai JP, Tsai MK, Yang YC, Cheng TY, Lee MC, Chan HT, Tsao CK, Tsai SP, Wu X. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378(9798):1244-53, 10/2011. PMID: 21846575.

筛选癌症药物遗传生物标志物

l  Lin SH, Raju GS, Huff C, Ye Y, Gu J, Chen JS, Hildebrandt MAT, Liang H, Menter DG, Morris J, Hawk E, Stroehlein JR, Futreal A, Kopetz S, Mishra L, Wu X. The somatic mutation landscape of premalignant colorectal adenoma. Gut, 67(7):1299-1305, 2018 Jul. PMID: 28607096.

l  Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Bostick RM, Wu X, Yuan Y. A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study. Am J Gastroenterol 112(5):704-715, 5/2017. PMID: 28323271.

l  Scelo G, Purdue MP, Brown KM, Johansson M, Wang Z, Eckel-Passow JE, Ye Y, Hofmann JN, Choi J, Foll M, Gaborieau V, Machiela MJ, Colli LM, Li P, Sampson JN, Abedi-Ardekani B, Besse C, Blanche H, Boland A, Burdette L, Chabrier A, Durand G, Le Calvez-Kelm F, Prokhortchouk E, Robinot N, Skryabin KG, Wozniak MB, Yeager M, Basta-Jovanovic G, Dzamic Z, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Szeszenia-Dabrowska N, Benhamou S, Cancel-Tassin G, Cussenot O, Baglietto L, Boeing H, Khaw KT, Weiderpass E, Ljungberg B, Sitaram RT, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Freeman LEB, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Wood C, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Mark Lathrop G, Rothman N, Deleuze JF, McKay JD, Parker AS, Wu X (co-last author), Houlston RS, Brennan P, Chanock SJ. Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nat Commun, 2017 Jun 9;8:15724. doi: 10.1038/ncomms15724. PMID: 28598434.

l  Berndt SI, Camp NJ, Skibola CF, Vijai J, Wang Z, Gu J, Nieters A, Kelly RS, Smedby KE, Monnereau A, Cozen W, Cox A, Wang SS, Lan Q, Teras LR, Machado M, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Vajdic CM, Cocco P, Zhang Y, Giles GG, Zeleniuch-Jacquotte A, Lawrence C, Montalvan R, Burdett L, Hutchinson A, Ye Y, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Cunningham JM, Allmer C, Hjalgrim H, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Arnett DK, Zhi D, Leach JM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Sala N, Casabonne D, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Chaffee KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Leis JF, Weinberg JB, Caporaso NE, Norman AD, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Southey MC, Milne RL, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Villano DJ, Maria A, Spinelli JJ, Gascoyne RD, Connors JM, Bertrand KA, Giovannucci E, Kraft P, Kricker A, Turner J, Ennas MG, Ferri GM, Miligi L, Liang L, Ma B, Huang J, Crouch S, Park JH, Chatterjee N, North KE, Snowden JA, Wright J, Fraumeni JF, Offit K, Wu X (co-last author), de Sanjose S, Cerhan JR, Chanock SJ, Rothman N, Slager SL. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat Commun 7:10933, 3/2016. PMCID: PMC4786871.

l  Mendoza-Pérez J, Gu J, Herrera LA, Tannir NM, Matin SF, Karam JA, Huang M, Chang DW, Wood CG, Wu X. Genomic DNA hypomethylation and risk of renal cell carcinoma: A case-control study. Clin Cancer Res 22(8):2074-82, 4/2016. PMCID: PMC4834236.

l  Wen CP, Zhang F, Liang D, Wen C, Gu J, Skinner H, Chow WH, Ye Y, Pu X, Hildebrandt MA, Huang M, Chen CH, Hsiung CA, Tsai MK, Tsao CK, Lippman SM, Wu X. The ability of bilirubin in identifying smokers with higher risk of lung cancer: a large cohort study in conjunction with global metabolomic profiling. Clin Cancer Res 21(1):193-200, 1/2015. PMCID: PMC4286447.

l  Cerhan JR, Berndt SI, Vijai J, Ghesquières H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, de Bakker PI, Nieters A, Cox D, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Lan Q, Severi G, Melbye M, Gu J, Jackson RD, Kane E, Teras LR, Purdue MP, Vajdic CM, Spinelli JJ, Giles GG, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SM, Witzig TE, Weiner GJ, Veron AS, Zelenika D, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami HO, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot T, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Kricker A, Turner J, Southey MC, Clavel J, Virtamo J, Weinstein S, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Vermeulen RC, Boeing H, Tjonneland A, Angelucci E, Di Lollo S, Rais M, Birmann BM, Laden F, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Sampson J, Liang L, Park JH, Chung CC, Weisenburger DD, Chatterjee N, Fraumeni JF, Slager SL, Wu X(co-last author), de Sanjose S, Smedby KE, Salles G, Skibola CF, Rothman N, Chanock SJ. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet 46(11):1233-8, 11/2014. PMCID: PMC4213349.

l  Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X. Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study. Clin Cancer Res 18(21):5983-91, 11/2012. PMCID: PMC3640870.

l  Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P. Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. J Natl Cancer Inst 103(10):817-25, 5/2011. PMCID: PMC3096796.

l  Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X (co-first author), Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF, Silverman DT, Chanock SJ. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet 42(11):978-84, 11/2010. PMCID: PMC3049891.

l  Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X (co-last author), Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol 11(4):321-30, 4/2010. PMCID: PMC2945218.

l  Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang ZF, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Guarrera S, Polidoro S, Chang SC, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9):991-5, 9/2009. PMCID: PMC3313685.

l  Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X. Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway are Associated with Clinical Outcomes in Esophageal Cancer Patients Treated with Chemoradiotherapy. J Clin Oncol 27(6):857-71, 2/2009. e-Pub 1/2009. PMCID: PMC2738430.

l  Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40(5):616-22, 5/2008. e-Pub 4/2008. PMCID: PMC2713680.

l  Wu X, Gu J, Wu TT, Swisher SG, Liao Z, Correa AM, Liu J, Etzel CJ, Amos CI, Huang M, Chiang SS, Milas L, Hittelman WN, Ajani JA. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. J Clin Oncol 24(23): 3789-98,2006. PMID: 16785472.

l  Rebbeck TR, Spitz M, Wu X. Assessing the function of genetic variants in candidate gene association studies. Nat Rev Genet 5(8):589-97, 2004. PMID: 15266341.

l  Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95(16):1211-8, 2003. PMID: 12928346.

利用高端的生物信息和生物统计方法建立整合性的风险预测模型并转成一系列个人预测模型的人工智能工具

l  Wu X, Ye Y, Barcenas CH, Chow WH, Meng QH, Chavez-MacGregor M, Hildebrandt MA, Zhao H, Gu X, Deng Y, Wagar E, Esteva FJ, Tripathy D, Hortobagyi GN. Personalized Prognostic Prediction Models for Breast Cancer Recurrence and Survival Incorporating Multidimensional Data. J Natl Cancer Inst 109(7), 7/2017. PMID: 28376179.

l  Wu X, Wen CP, Ye Y, Tsai M, Wen C, Roth JA, Pu X, Chow WH, Huff C, Cunningham S, Huang M, Wu S, Tsao CK, Gu J, Lippman SM. Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. Sci Rep 6:36482, 11/2016. PMCID: PMC5090352.

l  Wen CP, Lin J, Yang YC, Tsai MK, Tsao CK, Etzel C, Huang M, Hsu CY, Ye Y, Mishra L, Hawk E, Wu X. Hepatocellular Carcinoma Risk Prediction Model for the General Population: The Predictive Power of Transaminases. J Natl Cancer Inst 104(20):1599-611, 10/2012. PMCID: PMC3692381.

l  Wu X, Lin J, Grossman HB, Huang M, Gu J, Etzel CJ, Amos CI, Dinney CP, Spitz MR. Projecting Individualized Probabilities of Developing Bladder Cancer in Caucasians. J Clin Oncol 25(31):4974-81, 11/2007. PMID: 17971596.

 

教学与人才培养

教学工作

分子流行病学

肿瘤流行病学

 

研究生培养

UTHSC-SPH, Jegnish Shah, M.P.H. student, 9/1996-5/1997

UTHSC-SPH, Yan Wen Li, M.D, M.P.H. student, 9/1996-5/1997

UTHSC-SPH, Kei Shi, M.S. student, 1/1997-5/2000

UTHSC-SPH, Yan Wen Li, Graduate Student, 1997

UTHSC-SPH, Huai Lin, Ph.D. student, 9/1997-8/1998

UTHSC-SPH, Matthew B. Schabath, M.S. student, 1/1998-8/2000

UTHSC-SPH, Nimisha Makan, M.S. student, 1/1998-8/2000

UTHSC-SPH, Hua Zhao, M.S. student, 5/1999-9/2000

UTHSC-SPH, Qi Wei, M.P.H. student, 8/1999-7/2000

UTHSC-SPH, Darinka Perisic, M.D., M.P.H. student, 7/2000-5/2001

UTHSC-SPH, Matthew B. Schabath, Ph.D. student, 8/2000-12/2003

UTHSC-GSBS, Aditi Hazra, Ph.D. student, 8/2000-12/2004

UTHSC-SPH, Hua Zhao, Ph.D. student, 9/2000-8/2003

UTHSC-SPH, Edith Napoleon, M.P.H. student, 9/2002-5/2004

UTHSC-SPH, Khan Owis, M.P.H. student, 10/2003-8/2004

UTHSC-SPH, Nancy Tang, Ph.D. student, 3/2004-5/2008

UTHSC-GSBS, Maosheng Huang, Ph.D. student, 3/2004-8/2008

NCI R25T Predoc Fellowship in Cancer Prevention Program, Yale University, School of Public Health, Jessica Clague, M.P.H. student, 5/2005-8/2005

UTHSC-SPH, Manisha Jhamb, M.P.H. student, 8/2005-5/2006

UTHSC-GSBS, Meng Chen, Ph.D. student, 5/2006-8/2009

UTHSC-GSBS, Xia Pu, Ph.D. student, 7/2007-8/2012

UTHSC-GSBS, Jessica Clague, Ph.D. student, 8/2007-8/2009

NCI R25T Predoc Fellowship in Cancer Prevention Program, Yale University, School of Public Health, Samira Kamrudin, M.P.H. student, 5/2008-8/2008

UTHSC-GSBS, Shanyu Zhang, Ph.D. student, 1/2009-8/2009

China, JingYao Dai, Visiting Ph.D. student, 2010-2011

UTHSC-GSBS, Sarah Tambra, M.S. Student, 6/2010-5/2011

UTHSC-SPH, Jeanne Pierzynski, M.P.H Student, 6/2010-5/2012

UTHSC-SPH, Xiang Shu, Ph.D. Student, 9/2010-present

UTHSC-GSBS, Fanmao Zhang, Ph.D. Student, 1/2011-8/2014

UTHSC-GSBS, Lixia Han, Ph.D. Student, 3/2013-5/2015

UTHSC-GSBS, Shu-Hong Lin, Ph.D. Student, 3/2013-5/2018

UTHSC-GSBS, Jeanne Pierzynski, Ph.D. Student, 8/2013-12/2017

Kunlin Xie, Visiting Ph.D. Student, 3/2016-6/2018

Yanwei Zhang, Visiting Ph.D. Student, 9/2014-6/2015

UTHSC-SPH, Fang Yu Lin, Ph.D. Student, 12/2014-present

 

博士后培养

Dr. Juehui Liu, 11/1995-11/1996

Dr. Min Wang, 11/1997-2/1999

Dr. Yaohua Hu, 1/1998-10/1998

Dr. Huifeng Zhang, 11/1998-6/2004

Dr. Yunfei Wang, 12/1999-6/2004

Dr. Yong Zhu, 5/2000-12/2002

Dr. Kerang Zhang, 6/2000-5/2002

Dr. Seun-Ja Park, 7/2001-12/2001

Dr. Lina Shao, 7/2002-6/2005

Dr. Jie Lin, 1/2003-9/2005

Dr. Hua Zhao, 9/2003-10/2004

Dr. Matthew Schabath, 1/2004-8/2006

Dr. Hushan Yang, 6/2005-7/2009

Dr. Yuanqing Ye, 7/2006-5/2008

Dr. Michelle Hildebrandt, 7/2007-12/2009

Dr. Adrian Cassidy, 9/2007-10/2008

Dr. Xiaofan Zhang, 9/2008-9/2011

Dr. YiLei Gong, 2/2009-5/2011

Dr. Hua Wei, 2/2009-present

Dr. Meng Chen, 9/2009-8/2012

Dr. Hung-Lung Ke, 1/2010-2011

Dr. Yan Wang, 4/2010-4/2013

Dr. Wenjie Sun, 7/2011-7/2013

Dr. Jie Lian, 12/2011-12/2014

Dr. Beatriz Sánchez-Espiridión, 6/2012-2/2016

Dr. Anthony D'Amelio, 8/2012-12/2012

Dr. Xia Pu, 9/2012-8/2014

Dr. Xin Wang, 2/2013-4/2014

Dr. Stephanie Melkonian, 7/2013-9/2015

Dr. Huakang Tu, 7/2014-12/2018

Dr. Liren Zhang, 2/2015-12/2017

Dr. Hao Yu, 8/2015-10/2017

Dr. Yajie Zhang, Ph.D., 11/2017-10/2018

 

临床人才培养

Dr. Yanwen Li, NIOSH Fellow, 4/1996-9/1997

Dr. Tianying Yuan, NIOSH Fellow, 10/1996-5/1997

Dr. Lie Chen, NIOSH Fellow, 9/1997-10/1997

Dr. Dan Leibovici, Urology Oncology Fellow, 7/2003-6/2005

Dr. Salvador Saldivar, Gynecology Oncology Fellow, 7/2003-4/2006

Dr. Yimin Zhu, Visiting Scientist, 4/2005-6/2007

Dr. Jinliang Xing, Visiting Scientist, 4/2005-2/2008

Dr. Karim Kader, Urology Oncology Fellow, 7/2005-6/2007

Dr. Wei Wang, Visiting Scientist, 9/2005-5/2008

Dr. Yohei Horikawa, Visiting Scientist, 6/2006-5/2008

Dr. Angela Coscio, Hematology and Oncology Fellow, 9/2008-8/2010

Dr. Larissa Alejandra Meyer, Gynecologic Oncology Fellow, 10/2008-8/2011

Dr. Weiqi Tan, Visiting Scientist, 2/2009-11/2010

Dr. Jian-Ming Wang, Visiting Scientist, 5/2009-4/2010

Dr. Jikai Yin, Visiting Scientist, 5/2009-5/2011

Dr. Moubin Lin, Visiting Scientist, 6/2009-3/2011

Dr. Eric Kim, Hematology and Oncology Fellow, 1/2010-6/2012

Dr. Klaus Wagner, Hematology and Oncology Fellow, 2010-2013

Dr. Da-Tien Bau, Sister Institution Associate, 8/2010-2/2011

Dr. Yonggang He, Visiting Scientist, 4/2011-2014

Dr. Enping Xu, Visiting Scientist, 6/2011-6/2013

Dr. Saad Aldousari, Urology Oncology Fellow, 7/2011-2013

Dr. Hui Xie, Visiting Scientist, 12/2011-12/2012

Dr. Mario Fernandez, 1/2012-12/2012

Dr. Yuhui Sun, Visiting Scientist, 5/2013-5/2014

Dr. Rosalinda Mendoza, Visiting Scientist, 11/2013-4/2015

Dr. Rong Li, Visiting Scientist, 12/2013-3/2015

Dr. Julia Mendoza, Visiting Scientist, 12/2013-present

Dr. Lina Zhao, Visiting Scientist, 1/2014-2/2015

Dr. Xiaoan Liu, Visiting Scientist, 3/2014-9/2014

Dr. Stephen Williams, Urology Fellow, 4/2014-6/2016

MD Anderson Cancer Center, Dr. Li Zhang, Visiting Scientist, 5/2014-10/2014

MD Anderson Cancer Center, Dr. Wenquan Niu, Visiting Scientist, 6/2014-6/2015

Dr. Miguel Santibanez, Visiting Scientist, 12/2014-4/2015

MD Anderson Cancer Center, Dr. Yuan Mao, Visiting Scientist, 12/2014-6/2015

Dr. Yang Deng, Visiting Scientist, 5/2015-10/2016

Dr. Jianchun Gu, Visiting Scientist, 8/2015-10/2016

Dr. Qinchuan Wang, Visiting Scientist, 11/2015-10/2017

Dr. Jingfen Zhu, Visiting Scientist, 12/2015-12/2016

Dr. Meiling Zhu, Visiting Scientist, 12/2016-9/2018

 

其他人员培养

Mentor, Pooja Rohatgi, Baylor College of Medicine, 8/2005-5/2006

Mentor, Amy Tsou, High School Student, 2000

Mentor, Carla Blieden, College Program, 2000

Mentor, Leah Yieh, High School Student, 2002

Mentor, Mauricio Smart, College Program, 2004

Mentor, Yubo Gong, College Student, 2004

Mentor, Albert Ramirez, High School Student, 2005

Mentor, Hek Kevon Matdoost, College Student, 2005

Mentor, Joshua Chang, College Student, 2008-2011

Mentor, Yiyang Wu, High School student, 2008

Mentor, Luther Fan, High School student, 2009-2010

Mentor, Alice Jiang, High School student, 2009

Mentor, Cancer Prevention Research Training Program, Sonny Nguyen, College Student, 6/2012-8/2012

Mentor, Emily Wu, College Student, 7/2012-8/2012

Mentor, Tristan Lim, High School Student, 7/2012-8/2012

Mentor, Non-Competitive (Track 2) MD Anderson Summer Experience, Jaclyn Ly, Graduate Student, 6/2013-8/2013

Mentor, Tristan Lim, High School Student, 7/2014-8/2014

Mentor, MD Anderson Cancer Center, Jeremy Mani, College Student, 6/2015-7/2015

Mentor, MD Anderson Cancer Center, Gabriela Mata, High School Student, 6/2015-8/2015

Mentor, MD Anderson Cancer Center, Kierra Morris, High School Student, 6/2015-8/2015

Mentor, MD Anderson Cancer Center, Molly Lu, High School Student, 6/2015-8/2015

 

研究生学术委员会

Advisor, UTSPH, Gladstone Airewele, M.P.H. Advisory Committee, 9/1996-8/1998

Advisor, UTSPH, Karen Joanne Wiley, M.S. Advisory Committee, 1/1997-8/1998

Member, UTSPH, Joseph Anthony Trachier, M.P.H. Advisory Committee, 1/1997-9/2000

Member, UTSPH, Suzanne E. Hegemier, M.P.H. Advisory Committee, 1/1997-9/2000

Member, UTSPH, Lixing Zhang, Ph.D. Advisory Committee, 1/1997-12/2000

Member, UTSPH, Janice Marie Beal, M.P.H. Advisory Committee, 10/1997-9/2000

Advisor, UTSPH, Rosalyn B. Beaty, M.P.H. Advisory Committee, 1/1998-5/2000

Member, UTSPH, Francine Kay Kingston, M.P.H. Advisory Committee, 1/1999-5/2000

Member, UTSPH, Chris Henry Ojeih, M.P.H. Advisory Committee, 1/1999-9/2000

Advisor, UTSPH, Joseph Roth, M.S. Advisory Committee, 8/1999-9/2000

Advisor, UTSPH, Lisa Kennedy, M.S. Advisory Committee, 8/1999-9/2000

 

培养的人才所获奖项

1.     Matthew Schabath, AACR Scholar-in-Training Award, 2002

2.     Yong Zhu, 1st Place, MDACC Trainee Recognition Day, 2002

3.     Yong Zhu, AACR Scholar-in-Training Award, 2002

4.     Matthew Schabath, MDACC Trainee Recognition Award, 2003

5.     Matthew Schabath, AACR Scholar-in-Training Award, 2003

6.     Aditi Hazra, Andrew Sowell-Wade Huggins Scholar Award, 2003

7.     Matthew Schabath, AACR Scholar-in-Training Award, 2005

8.     Matthew Schabath, AACR Scholar-in-Training Award, 2006 

9.     Maosheng Huang, AACR Scholar-in-Training Award, 2006 

10.  Yuanqing Ye, Poster Winner, MDACC Trainee Recognition Day, 2007 

11.  Matthew Schabath, Benard Levin 1st Place Poster Award, 2007 

12.  Maosheng Huang, AACR Scholar-in-Training Award, 2007

13.  Yuanqing Ye, AACR Scholar-in-Training Award, 2007 

14.  Hushan Yang, 1st Place, MDACC Trainee Recognition Day, 2007 

15.  Meng Chen, International Society of Gastrointestinal Oncology-Trainee Award, 2007 

16.  Jinliang Xing, International Society of Gastrointestinal Oncology-Trainee Award, 2007 

17.  Jessica Clague, Graduate Student Poster Award, Trainee Recognition Day, 2008 

18.  Michelle HIldebrandt, Postgraduate Poster Award, Trainee Recognition Day, 2008 

19.  Hushan Yang, 2nd Place, MDACC Trainee Recognition Day, 2008 

20.  Meng Chen, AACR Frontiers on Cancer Prevention Research Trainee Award, 2008 

21.  Jessica Clague, Division of Cnacer Prevention Trainee Award, 2008 

22.  Jessica Clague, AACR Frontiers on Cancer Prevention Scholar-in-Training, 2008

23.  Xia Pu, AACR Scholar-in-Training Award 2009 

24.  Xia Pu, 2nd Place, MDACC Trainee Recongnition Day, 2009 

25.  Meng Chen, AACR Scholar-in-Training Award, 2009 

26.  Hushan Yang, AACR Scholar-in-Training Award, 2009 

27.  Michelle Hildebrandt, MDACC Trainee of the Quarter, 2009 

28.  Michelle Hildebrandt, MDACC Trainee Excellence Award, 2009 

29.  Michelle HIldebrandt, AACR Frontiers in Cancer Prevention Scholar-in-Training Award, 2009 

30.  Klaus Wagner, ASCO Clinical Fellow Merit Award, 2010 

31.  Eric Kim, ASCO Clinical Fellow Merit Award, 2010 

32.  Meng Chen, AACR Scholar-in-Training Award, 2010 

33.  Klaus Wagner, MDACC Trainee Excellence Award, 2010 

34.  Eric Kim, AACR GlaxoSmithKline Clinical Cancer Research Scholar Award, 2011

35.  Xia Pu, AACR Scholar-in-Training Award, 2011

36.  Xia Pu, AACR Scholar-in-Training Award, 2012

37.  Xia Pu, AACR Scholar-in-Training Award, 2013

38.  Fanmao Zhang, MD Anderson Trainee Excellence Award, 2013 

39.  Shu-Hong Lin, MD Anderson Trainee Research Day - Oral Competition, 1st Place (Grad/Undergrad) -  Clinical Research, 2014

40.  Xia Pu, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Postdoc/Clinical Fellows) -Population Science, 2014

41.  Jeanne Pierzynski, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Grad/Undergrad) - Population Science, 2014

42.  Stephanie Melkonian, MD Anderson Trainee Research Day - Oral Competition Finalist, (Postdoc/Clinical Fellows) - Population Science, 2014

43.  Fanmao Zhang, MD Anderson Trainee Research Day - Oral Competition Finalist (Grad/Undergrad) - Population Science, 2014

44.  Beatriz Sanchez Espiridion, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2014

45.  Jie Lian, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2014

46.  Xin Wang, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical            Fellows) - Population Science, 2014

47.  Lixia Han, MD Anderson Trainee Research Day - Poster Competition Finalist (Grad/Undergrad) -             Population Science, 2014

48.  Jeanne Pierzynski - Predoctoral R25T Cancer Prevention Fellowship Award, April 2014 

49.  Stephanie Melkonian - MD Anderson Trainee Research Day - Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Population Science, 2015 

50.  Beatriz Sanchez Espiridion, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2015

51.  Huakang Tu, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Population Science, 2015 

52.  Jeanne Pierzynski, MD Anderson Trainee Research Day - Poster Competition, 1st Place (Grad/Undergrad) - Population Science, 2015 

53.  Stephen Williams, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Basic Sciences, 2015

54.  Xiang Shu, MD Anderson Trainee Research Day - Poster Competition Finalist (Postdoc/Clinical Fellows) - Translational Research, 2015

55.  Stephen Williams, Comparative Effectiveness Resarch on Cancer in Texas (CERCIT) Scholar, 2015

56.  Stephen Williams, Conquer Cancer Foundation, American Society of Clinical Oncology Merit Award, 2015

57.  Stephen Williams, Société Internationale d'Urologie (SIU) United States National Chapter, Traveling Scholarship Award, 2015

58.  Liren Zhang, AACR Scholar-in-Training Award, 2016

59.  Jeanne Pierzynski, AACR Scholar-in-Training Award, 2016

60.  Huakang Tu, Ph.D., - MD Anderson Trainee Research Day - Oral Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Population Science, 2017

61.  Huakang Tu, Ph.D., - MD Anderson Trainee Research Day - Oral Oral Competition, 1st Place (Postdoc/Clinical Fellows) - Clinical Research, 2018 

 

学术兼职

l  美国国家卫生研究院, Cancer Genetics Study Section, 课题评审委员会专家(2013-2019)

l  美国国防部科研基金, Lung Cancer Research Program Concept Award,评审专家(2011-2017)

l  欧盟研究基金会, ERC Starting Grants Panel, Genetic, Genomics, Bioinformatics and Systems Biology, 课题评审委员会专家(2015-至今)

l  英国癌症研究基金,Population Research Committee,课题评审委员会专家(2015-至今)

l  美国国家卫生研究院 P01 重大项目基金,评审委员会专家(2004、2005、2007、2009、2010、2011、2012、2013、2014、2016、2017)

l  美国国家卫生研究院,Special Emphasis Panel (SEP) - Loan Repayment Program,课题评审委员会专家(2010、2011、2012、2013、2014、2015、2016)

l  国际膀胱癌协会联合创始人,协调委员会主席(2011-2017)

l  美国癌症研究学会(AACR)癌症流行病学和预防会议学术奖评比委员会委员(2014-2016)

l  中国国家分子医学转化科学中心顾问委员会委员(2015-2018)

l  美国癌症协会(ACS),Clinical Cancer Research and Epidemiology (CCE),课题评审委员会专家(2008-2013)

l  美国国家卫生研究院, NCI Intramural Program,评审专家(2010、2013)

l  美国国家卫生研究院,Epidemiology of Cancer Study Section (EPIC),课题评审委员会专家(2004,2005-2009, 2010)

l  美国国家卫生研究院, Small Grant for Cancer Research and Cancer Epidemiology Study Section,课题评审委员会专家(2005-2006)

l  美国国家癌症研究中心PREPAC项目专家顾问委员会成员(2006-2011)

l  美国癌症研究中心上海女性健康研究队列特邀顾问(2013-2017)

l  AACR年会流行病组科学评审委员会共同主席(2012)

l  AACR癌症预防研究进展年会科学评审委员会共同主席(2012)

l  Landon-AACR国际创新奖评审委员会委员(2009-2010)

l  波兰国家科学中心, 课题评审委员会专家(2015)

l  美国国家癌症研究中心, Outstanding Investigator Award Initiative,评审委员会专家(2015)

l  香港卫生署,课题评审专家(2009、2010、2014、2015、2016)

l  美国癌症研究所(AICR), 课题评审专家(2014)

l  英国Wellcome Trust基金,课题评审专家(2006, 2014)

l  西班牙加泰罗尼亚健康信息评估中心,课题评审专家(2013)

l  法国国家生命和健康科学联盟,课题评审专家(2013)

l  世界癌症研究基金会, 课题评审专家(2013)

l  英国癌症研究基金,Science Funding Review Panel/Programme Grant Review,课题评审委员会专家(2006-2009, 2009-现在)

l  美国癌症研究学会,Innovator Award for International Collaboration in Cancer Research,评审委员会专家(2012)

l  卡塔尔国家科研基金会,课题评审专家(2010)

l  新加坡国家医学研究资助委员会,课题评审专家(2010)

l  荷兰癌症协会,课题评审专家(2010)

l  意大利Istituto Toscano Tumori基金,课题评审专家(2009-2015)

l  美国国家卫生研究院, GGG Shared Instrumentation,课题评委员会审专家(2009)

l  美国国家卫生研究院,Transdisciplinary Research on Energetics and Cancer (TREC) and TREC Coordinating Centers Study Section, 课题评审委员会专家(2005)

l  Cancer Research杂志常务编委(2008-2012)

l  近50家知名杂志审稿人,包括New England Journal of Medicine, Lancet, JAMA, Nature Genetics, Journal of Clinical Oncology, Journal of the National Cancer Institute等


奖励及荣誉

2016年,获肿瘤预防杰出导师奖,MD安德森癌症中心

2015年,获国际结直肠癌多学科诊治会议杰出贡献奖

2014年,获休斯顿市50位最具影响力女性奖

2012,2011,2010,2009,2008,2007年,获卓越的领导和支持导师证书

2011年,获Robert M. Chamberlain 杰出导师奖,MD安德森癌症中心

2010年,获肿瘤预防杰出导师奖,MD安德森癌症中心

2008年,获Margaret and James A. Elkins, Jr.肿瘤预防杰出成就奖,MD安德森癌症中心

2008年,获Julie and Ben Rogers基础科研成就奖,MD安德森癌症中心

2008年,获MD安德森基金资深院士. 这一称号可获175万美元资助。MD安德森有6位获这称号

2008年,授予癌症预防Betty B. Marcus冠名主席

2007年,获最佳老板入围奖

2006年,授予Ashbel Smith冠名教授

2002年,获杰出学者奖,MD安德森癌症中心