|Departments:||Department of Neurobiology|
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Shumin Duan is a professor and the dean of Zhejiang University School of Medicine, Hangzhou, China. He graduated from Bengbu Medical College in China in 1982 and received his Ph. D. from Kyushu University in Japan in 1991. He received a postdoctoral training at University of Hawaii and University of California at San Francisco during 1997-1999. He worked as a principal investigator in Institute of Neuroscience in Shanghai, Chinese Academical Sciences from 2000 to 2009. His research interests focuses on synapses and the function and the mechanisms of neuron-glia interactions in health and disease. He has made a number of contributions in the field of glial cell studies, including the roles of glial cells in synaptic plasticity and mechanisms of signaling molecule release from glial cells. He is an academician of Chinese Academy of Sciences and a member of the Academy of Sciences for the Developing World (TWAS). He is the president of Chinese Society for Neuroscience and a council member of International Brain Research Organization of Society for Neuroscience. He is the Editor-in-Chief of Neuroscience Bulletin, the official journal of Chinese Society for Neuroscience. He serves as an editorial board member in several international neuroscience journals, including Journal of Neurophysiology, Glia, Neurobiology of Disease, Hippocampus, Cell Calcium, and Plos One.
(* Corresponding author)
1.Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng GP, Huang ZL, Duan* , and Yu YQ, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions, Current Biology 2014 ( in press)
2.Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z, Duan S.
Analysis of microglial migration by a micropipette assay. Nat Protoc. 2014, 9: 491-500.
3.Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013, 33: 4282-93.
4.Chen J, Tan Z, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S*. Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. 2013，61:178-191
5.Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S*, Zheng J*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012, 30:2571-2583
6.Y Dou, HJ Wu, HQ Li, S Qin, HF Lou, QM Luo, Duan S*, Microglia Migration Mediated by ATP-Induced ATP Release from Lysosome, Cell Res, 2012 22:1022-1033
7.Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan S, Li XM. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2012: 15,267–273
8.Ji Y, Lu Y, Yang F, Shen W, Tang TT, Feng L, Duan S, Lu B,.Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci. 2010, 13:302-309
9.Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter for cytoplasmic transport at the axon initial segment. Cell. 2009, 136:1148-1160.
10.Tong XP, Li XY, Zhou B, Shen WH, Zhang ZJ, Xu TL, Duan S*，Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J Cell Biol, 2009, 186: 113-128
11.Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2 Signaling Is Critical for Dendrite Branching. Mol Biol Cell. 2008, 19: 4804-4813
12.Z-J Zhang, G Chen, W Zhou, A-H Song, W Wang, T Xu, Q-M Luo, X-S Gu, Duan S*, Regulated ATP release from astrocytes via lysosome exocytosis. Nature Cell Biol 2007, 9: 945-953.
13.Ge WP, Duan S*. Persistent Enhancement of Neuron-Glia Signaling Mediated by Increased Extracellular K+ Accompanying Long-Term Synaptic Potentiation. J Neurophysiol. 2007, 97: 2564-2569
14.Chen G, Li HM, Chen YR, Gu XS, Duan S*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 2007; 55:1509-1518.
15.Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007, 134:901-908.
16.Wang, C., Zhang, L., Zhou, Y., Zhou, J., Yang, X., Duan, S., Xiong, Z., Ding, Y. (2007) Activity-dependent development of callosal projections in the somatosensory cortex. J. Neurosci. 27: 11334-11342
17.Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, Duan S* Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors Science, 2006，312, 1533-1537
18.Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuorn, 2006, 50: 401-414 (Cover)
Comment： Atasoy and Kavalali，Presynaptic Unsilencing: Searching for a Mechanism. Neuron, 2006, 50:345-346
19.Duan S*, Neary J, P2X7/P2Z receptors: properties and relevance to CNS functions (Invited review). Glia, 2006, 54:738-746.
20.Lu W, Zheng BJ, Xu K, Schwarz W, Du L, Wong CK, Chen J, Duan S, Deubel V, Sun B. Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. PNAS, 2006, 103:12540-12545
21.Jin W, Ge WP, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M, Xia J. Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity. J Neurosci. 2006 Mar 1;26(9):2380-90.
22.Xu X, Fu AK, Ip FC, Wu CP, Duan S, Poo MM, Yuan XB, Ip NY. Agrin regulates growth cone turning of Xenopus spinal motoneurons. Development. 132:4309-4316. (2005)
23.Pan, P., Cai, Q., Lin, L., Lu, P., Duan S*, and Sheng, Z. SNAP-29-mediated Modulation of Synaptic Transmission in Cultured Hippocampal Neurons. J. Biol.Chem. 280: 25769-25779 (2005)
24.Xu, H., Yuan, X., Guan, C., Duan, S., Wu, C., and Feng, L. Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration. PNAS, 101, 4296-4301 (2004)
25.Li, C., Wu, CP., Duan S*, and Poo, M. Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron，41, 257–268 （2004）
26.Zhang, J. Wang, H., Ye, C., Ge, W., Chen, Y., Wu, CP., Poo, M., and Duan, S. ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron, 40, 971-982 (2003)
Comment：O Pascual and PG. Haydon, Synaptic Inhibition Mediated by Glia. Neuron, 40, 873-875 (2003)
27.Yang, Y., Ge, W., Chen, Y., Wu, CP., Poo, M., and Duan, S*. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS, 100, 15194 – 15199 (2003)
28.Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell. 4:19-29 （2003）.
29.Wang, Z., Xu, N., Wu,CP., Duan S*，and Poo, M. Bidirectional Changes in Spatial Dendritic Integration Accompanying Long-Term Synaptic Modifications. Neuron, 37: 463-472 (2003)
30.Yuan X, Jin, M., Xu, X., Wu, CP., Poo, M., and Duan, S*. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nature Cell Biol, 5, 38 - 45 (2003)
31.Duan, S, C M. Anderson, E C. Keung, K.Farrell, Y. Chen, and RA. Swanson. P2X7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes. J Neurosci, 23: 1320-1328 (2003)
32.Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA. Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. J Neurosci. 22:9203-9209.（2002）
33.Xiang Y, Li Y., Zhang Z., Wang S., Yuan XB., Wu CP, Poo MM and Duan S*, Nerve growth cones guidance mediated by G-protein-coupled receptors. Nature Neuroscience, 5, 843 - 848 (2002)
34.Duan S, Cooke IM, Glutamate and GABA activate different receptors and Cl (-) conductances in crab peptide-secretory neurons. J Neurophysiol 83: 31-37 (2000)
35.Swanson R.A., Duan S., Regulation of glutamate transporter function (Review). Neuroscientist, 5: 280-282 (1999)
36.Duan S, Anderson CM, Stein BA, Swanson RA, Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. J Neurosci 19：10193-10200 (1999)
37.Duan S, Cooke IM, Selective inhibition of transient K+ current by La3+ in crab peptide-secretory neurons. J Neurophysiol 81:1848-1855 (1999)
Selected Invited talks
1.COLD SPRING HARBOR ASIA CONFERENCES，Development, Function and Disease of Neural Circuits，October 21-25, 2013，Suzhou
2.Gordon Research Conference on “Glial Biology: Functional Interactions Among Glia & Neurons”, March, 2013, Ventura, CA (USA)
3.Gordon Research Conference Molecular & Cellular Neurobiology, June 17-22, 2012, Hong Kong
4.Gordon Research Conference on Myelin Feb 14-19, 2010，Ventura, USA
5.Cold Spring Harbor Asia Conferences, Francis Crick Symposium on Neuroscience, April 12 - 17, 2010, Suzhou, China
6.5th Congress of Federation of Asian and Oceanian Neuroscience Societies, Nov 25 – 28, 2010, November 25 – 28, 2010, Lucknow, India
7.The 9th European Meeting On Glial Cells In Health and Disease. 2009, September 8-12, Paris, France (Plenary Lecture)
8.International Symposium on Purinergic Signalling in New Strategy of Drug Discovery , July 23-25, 2009, Fukuoka, Japan
9.Gordon Research Conference on “Glial Biology: Functional Interactions Among Glia & Neurons”, March 15-20, 2009, Ventura, CA (USA)
10.Gordon Research Conference on “Neurobiology of Brain Disorder ”, August 24-29, 2008, Oxford, United Kingdom
11.Gordon Research Conference on “Molecular & Cellular Neurobiology ”, Jun 8-13, 2008, Hong Kong, China
12.Cold Spring Harbor Laboratory Meeting “Glia in Health & Disease”, July 17 - 21, 2008, Cold Spring Harbor (USA)
13.Gordon Research Conference on “Glial Biology: Functional Interactions Among Glia & Neurons”, March 11-16, 2007, Ventura, CA (USA)
14.Gordon Research Conference on “Excitatory Synapses and Brain Function” , June 10-15, 2007,Colby-Sawyer College in New London, New Hampshire (USA)
15.Gordon Research Conference on "Neurotrophic Factors", June 17-22, 2007, Salve Regina University in Newport, Rhode Island
16.Symposium in the 7th IBRO WORLD CONGRESS OF NEUROSCIENCE: Purine mediated neuron-glia interactions: physiological and pathological relevance (Chair). Melbourne, Australia, 12-17 July, 2007.
17.Neuron-glia crosstalking in synaptic plasticity and neuronal signaling integrations. International symposium on Glial Activities in Neural Plasticity and Information Processing. Jan 2005, Tokyo
18.Gordon Research Conference (GRC), Glial Biology: Functional Interactions Among Glia and Neurons, March, 2005, Ventura, CA, USA
19.The 20th BIENNIAL MEETING of the International Society for Neurochemistry (ISN), Symposium: Glial cells as therapeutic targets for neurological disorders. Aug 2005, Innsbruck, Austria