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Name: Li Xiao-Ming
Post Professor
Position: PI
Education Ph.D.
Professional Neurobiology
Departments Department of Neurobiology
Research Neurobiology of Disease
TEL: 0571-88208002
E-mail: lixm@zju.edu.cn
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Profile
Dr. Xiao-Ming Li is a “Changjiang” Scholar Distinguished Professor and PI at Institute of Neuroscience of Zhejiang University School of Medicine and the professor at the university of Toronto. He earned the M.D. from First Military Medical University in 1996 and Ph.D. in 2003. He worked as a Resident Physician, Attending Physician at Hospital of Chinese People's Liberation Army during 1996-2004. He got his postdoctoral training at Dept. of Neurology, Medical College of Georgia, USA during 2005-2007. After that, he worded as an Assistant Research Scientist at Institute of Molecular Medicine and GeneticsMedical College of Georgia, USA from 2007-2008. In August, 2008, he joined Zhejiang University. Now he is the Executive Dean of Zhejiang University School of Medicine, the Executive Director of Institute of Neuroscience of Zhejiang University and the Director of the Brain Center of Affiliated Sir Run Run Shaw Hospital, also the General Secretary of Zhejiang Society for Neuroscience.

Prof. Li’ main research interest is to understand the molecular mechanisms underlying the formation, maintenance and regulation of synapses and neural circuits, in identifying targets to develop therapeutic strategies for treating neuropsychiatric disorders including schizophrenia, autism, and epilepsy. He has made important achievements in the field of the development and molecular regulation of synapses and circuits, especially in the pathogenesis of schizophrenia and epilepsy. His representative papers have been published on“Nature Neuroscience”,“Cell Research”,“elife”,“Journal of Neuroscience”, “Cerebral cortex” and so on. His research supports include Distinguished Young Scholars, National Natural Science Foundation of China; National Key Basic Research Developing Project, 973 project and so on.
 

Representative publications

Corresponding author

1. Zhu JM, Li KX, Cao SX, Chen XJ, Shen CJ, Zhang Y, Geng HY, Chen BQ, Lian H, Zhang JM, Li XM*. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Scientific Reports, 7: 141 (2017).

2.Pan G, Yang JM, Hu XY, Li XM*. Postnatal development of the electrophy -siological properties of somatostatin interneurons in the anterior cingulate cortex of mice. Scientific Reports. 6:28137 (2016).

3. Zhang Y, Cao SX, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg DK, Duan SM, Li XM*. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via the α7 receptor in the hippocampus. Cell Research, 26(6):728-42 (2016).

4. Ni KM, Hou XJ, Yang CH, Dong P, Li Y, Zhang Y, Jiang P, Berg DK, Duan SM, Li XM*. Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. eLife, 5. pii: e10382 (2016).

5. Pan G, Li Y, Geng HY, Yang JM, Li KX, Li XM*, Preserving GABAergic interneurons in acute brain slices of mice using the N-methyl-D-glucamine-based artificial cerebrospinal fluid method. Neuroscience Bull, 31(2),265-70(2015).

6. Lu YM, Gao YP, Tao RR, Liao MH, Huang JY, Wu G, Han F, Li XM*, Calpain-dependent ErbB4 cleavage is involved in brain ischemia-induced neuronal death. Molecular Neurobiology, 53(4):2600-9 (2015).

7. Yang JM, Zhang J, Yu YQ, Duan SM, Li XM*, Postnatal development of 2 microcircuits involving fast-spiking interneurons in the mouse prefrontal cortex. Cerebral Cortex, 24(1),98-109(2014).

8. Hou XJ, Ni KM, Yang JM, Li XM*, Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses. Neuroscience,261,107-117(2014).

9. Yang JM, Zhang J, Chen XJ, Geng HY, Ye M, Spitzer NC, Luo JH, Duan SM, Li XM*. Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice. Journal of Neuroscience, 33(50),19724-19733(2013).

10. Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan SM, Li XM*, Neuregulin1 signaling regulates excitability of fast-spiking interneurons via Kv1.1 and acts Epilepsy. Nature Neuroscience, 15(2),267-273(2012).


Co-author

1. Zhao CY, Zhang J, Li KX, Yang JM, Yu HM, Duan SM, Jiang KW, Li XM, β-catenin regulates membrane potential in muscle cells through regulation of α2 subunit of Na-K-ATPase. European Journal of Neuroscience, 40(1),2216-24(2014).

2. Wu HJ, Liu YJ, Li HQ, Chen Q, Dou Y, Lou HF, Ho MS, Li XM, Duan SM, Gao ZH, Analysis of microglial migration by a micropipette assay. Nature protocols, 9,491–500(2014).

3. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan SM, Yu YQ. selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Current Biology, 24(6), 693-8(2014).

4. Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1pyramidal neuronal death after transient global ischemia. Cell Death and Diseases, 27,5:e1541(2014).

5. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM. A novelsize-based sorting mechanism of pinocytic luminal cargoes in microglia. Journal of Neuroscience, 33(21),4282-4293.3(2013).

6. Li, H.Q., Chen, C., Dou, Y., Wu, H.J., Liu, Y.J., Lou, H.F., Zhang, J.M., Li XM, Wang H., Duan S., P2Y4 receptor-mediated macropinocytosis contributes to Aß-induced self-uptake by microglia. Molecular Cell Biology, 33(21),4282-4293(2013).

7. Dou Y, Wu HJ, Li HQ, Qin S, Wang YE, Li J, Lou HF, Chen Z, Li XM, Luo QM, Duan SM. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Research, 22(6),1022-33.62(2012).

8. Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH. Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway. Journal of Neuroscience, 32(35),11919-29(2012).

9. Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiology Disease, 48(1), 20-6(2012).