个人简介:浙江大学求是特聘教授，美国心脏协会会士（Fellow of AHA）。长期从事心血管生物学的研究，在干细胞治疗心血管疾病、及衰老对干细胞活性的影响等领域有深入的研究和积极的贡献。在Circulation Research，PNAS，ATVB， Stem Cell等国际著名学术期刊上发表论文八十余篇，以及8部书籍的章节。2011年回国后，已成功申请和参与了国家科技部973项目及重大科学研究计划项目和国家自然科学基金面上项目。

主要研究方向：干细胞治疗心血管疾病；干细胞动员，迁移，归巢和分化机制，及其在心肌修复中的作用；衰老对干细胞生物活性及其促血管新生能力的影响；干细胞分泌的外泌体exosome对心血管病的影响， 血管钙化的防治。 

学习和工作经历

1978—1982     上海复旦大学生物系            本科

1987—1993      美国南加州大学                     博士研究生

1997 —2002  美国南加州大学医学院              助理教授

2003 —2011    美国迈阿密大学医学院        副教授

2011—现在       浙江大学求是特聘教授 

近期发表的代表性论文

1.      Yang F, RR Wu, Z Jiang, J Chen, JL Nan, SA Su, N Zhang, C Wang, J Zhao, C Ni, YC Wang, WX Hu, ZR Zeng, KY Zhu, XB Liu, XY Hu, W Zhu, H Yu, and JY Huang, JA Wang. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death and Disease. 2018 March 30, In press.

2.      Shen J, N Zhang, YN Lin, PP Xiang, XB Liu, PF Shan, XY Hu, W Zhu, YL Tang, KA Webster, RZ Cai, A Schally, JA Wang, H Yu* Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists.  Circulation Research, April 4, 2018.  https://doi.org/10.1161/CIRCRESAHA.117.312418

3.      Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT, Hu X, Wang J.  Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circulation Research. 122:958-969 Jan 17, 2018;

4.      Ruan Xf, Li YJ, Ju CW, Shen Y, Lei W, Chen C^, Li Y, Yu H, Liu YT, Kim IM, Wang XL, Weintraub NL, Tang YL. Exosomes from Suxiao Jiuxin Pill-treated cardiac mesenchymal stem cells down-regulate H3k27 demethylase UTX expression in cardiomyocytes. Acta Pharmacologica Sinica. 2018,  Apr;39(4):579-586

5.      Ruan Xf, Ju CW, Shen Y, Liu YT, Kim IM, Yu H, Weintraub NL, Wang XL, Tang YL.   Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro. Acta Pharmacologica Sinica. 2018, Apr;39(4):569-578

6.      JY Zhu, K Lu, N Zhang, Y Zhao, QC Ma, J Shen, YN Lin, PP Xiang, YL Tang, XY Hu, JH Chen , W Zhu, KA Webster, JA Wang, H Yu*.  Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artificial Cells, Nanomedicine and Biotechnology. 2017. Nov 16:1-12.

7.      Zhou Y, Chen PP, Liu QN, Wang YC, Zhang L, Wu RR, Chen JH, Yu H, Zhu W, Hu XY, and Wang JA. Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury.  Stem Cells International, Vol. 2017, November Article ID 1096980, 12 pages, 2017. doi:10.1155/2017/1096980.

8.      Hu DX, Nan JL, Sun Y, Zhu D, Xiao CC, Wang YP, Zhu LL, Wu Y, Zhao J, Wu RR, Chen JH, Yu H, Hu XY, Zhu W, Wang JA. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A., 2017, Nov 7;114(45):11908-11913.

9.      Jin-Liang Nan; Wei Zhu; Rahman MS; Mingfei Liu; Sheng'an Su; Na Zhang; Dan Li; Xinyang Hu; Hong Yu; Mahesh P Gupta; Jian'an Wang. Molecular Regulation of Mitochondrial Dynamics in Cardiac Disease. BBA - Molecular Cell Research. 2017, Jul; 1864(7):1260-1273.

10.  Hu DX, Z Zeng, W Zhu, N Zhang, H Yu, H Chen, K Wang, YC Wang, LM Wang, J Zhao, L Zhang, RR Wu, XY Hu, XB Liu, JA Wang.  SRT1720 Promotes Survival of Aged Human Mesenchymal Stem Cells via FAIM: a Pharmacological Strategy to Improve Stem Cell Based Therapy for Rat Myocardial Infarction。Cell Death and Disease. 2017 Apr 6;8(4):e2731.

11.  Yu H, K Lu, JY Zhu, JA Wang*. Stem Cell Therapy for Ischemic Heart Disease. British Medical Bulletin. 2017 Feb 06 , 121 (1): 135-154. DOI: 10.1093/bmb/ldw059

12.  Wang C, H Chen, W Zhu, MF Liu, YC Xu, LL Zhu, F Yang, L Zhang, XB Liu, Z Zhong, J Zhao, J Jiang, M Xiang, Yu H, X Hu, H Lu, and JA Wang. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells。Arteriosclero Thromb Vasc Biol. 2017 Jan; 37(1):53-65.

13.  Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016 Nov;21(6):723-736.

14.  Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2016 Aug 29. pii: sctm.2015-0386.

15.  Ying-Mei Feng, Catherine Verfaillie, and Hong Yu. Vascular Diseases and Metabolic Disorders, Editorial. Stem Cells Int. 2016 Oct 20, Volume 2016, Article ID 5810358.

16.  Adi N, Adi J, Lassance-Soares RM, Kurlansky P, Yu H, Webster KA. High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice association with diet/genetics-regulated micro-RNAs.  J Diabet Metabol. 2016 Jun 16, 7:676; DOI: 10.4172/2155-6156.1000676 （IF 4.101）

17.  Boden J, Lassance-Soares RM, Wang H, Wei Y, Spiga MG, Adi J, Layman H, Yu H, Vazquez-Padron RI, Andreopoulos F, Webster KA. Vascular Regeneration in Ischemic Hindlimb by Adeno-Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor. J Am Heart Assoc. 2016 May 26;5(6). pii: e001815. doi: 10.1161/JAHA.115.001815.

18.  Ma Q, X Xia, Q Tao, K Lu, J Shen, Q Xu, X Hu, Y Tang, NL Block, KA Webster, AV Schally, Wang J, H Yu*. Profound actions of an agonist of growth hormone releasing hormone on angiogenic therapy by mesenchymal stem cells. Arteriosclero Thromb Vasc Biol. 2016;36:663-672.

19.  Hu X, Y Xu, ZW Zhong, Y Wu, J Zhao, Y Wang, HF Cheng, MJ Kong, FJ Zhang, Q Chen, JZ Sun, Q Li, J Jin, QJ Li, LH Chen, C Wang, HW Zhan, Y Fan, Q Yang, L Yu, RR Wu, J Liang, JY Zhu, Y Wang, YP Jin, YF Lin, F Yang, LL Jian, W Zhu, JH Chen, H Yu, JY Zhang, J Wang. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization.  Circ Res. 2016. 118(6):970-83. 

20.  Xia XY, Q Tao, Q Ma, H Chen, JA Wang, and Yu H*. Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis, Stem Cells Int. 2016 Oct 20, Volume 2016 Article ID 8737589.

21.  Yang ZX, Wang YZ, Jia BB, Mao GX, Lv YD, Wang GF, Yu H*. Down-regulation of miR-146a，COX-2 and AGEs in simvastatin treated elder patients with hyperlipidemia  Geriatrics & Gerontology International  2016; 16:322-328. doi: 10.1111/ggi.12472.

22.  Yu H, K Lu, JA Wang. Treatment of heart failure after myocardial infarction with bone marrow-derived mesenchymal stem cells (Review). Cardiol Plus. 2015 Sept; 1(1) 17-23.

23.  Hu X, L Zhang, J Jin, W Zhu, Y Xu, Y Wu, Y Wang, H Chen, KA.Webster, H Chen, H Yu, J Wang. Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015, Jun;33(6):1850-62.

24.  X Hu, R Wu, Z Jiang, L Wang, P Chen, L Zhang, L Yang, Y Wu, H Chen, H Chen, Y Xu, Y Zhou, X Huang, KA Webster, H Yu*, JA Wang* . Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells, July 3, 2014; 32:2702–2713

25.  MS Zhou, A Wang, H Yu. Link between Insulin Resistance and Hypertension: What is the Evidence from Evolutionary Biology? Diabetology & Metabolic Syndrome.  2014 Jan 31，6:12. 1-8.  doi:10.1186/1758-5996-6-12.

26.  Z Zhang, J Wang, Y Xu, Z Jiang, R Wu, L Wang, P Chen, X Hu, H Yu. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction.  Intl J Cardiol 2013 Sep 30;168(2):1711-4. doi: 10.1016/j.ijcard.2013.03.126.

27.  Xu Q, Wang JA, He J, Zhou MS, Adi J, Webster K, Yu H.* Impaired CXCR4 Expression and Cell Engraftment of Bone Marrow-derived Cells from Aged Atherogenic Mice. Atherosclerosis. 219:92-99,  2011

28.  Shao H, Xu Q, Wu Q, Ma Q, Slgueiro L, Wang JA, Eton D, Webster K, Yu H.* Defective CXCR4 Expression in Aged Bone Marrow Cells Impairs Vascular Regeneration. J Cell Mol Med. 15(10):2046-2056, 2011。

29.  Eton D, Yu H. Enhanced Cell Therapy Strategy to Treat Chronic Limb Threatening Ischemia. J Vasc Surg. 52（1）:199-204; 2010 doi:10.1016/j.jvs.2009.12.048

30.  Wu Q., Shao H, D. Eton, J Li. B Yang, M. G. Uberti, KA Webster, H. Yu*  Extracellular calcium increases CXCR4 Expression on Bone Marrow-derived Cells and Enhances Pro-Angiogenesis Therapy.  J Cell Mol Med. 13(9B):3764-3773. 2009.

31.  Shao H, Tan, Y, D. Eton, Z. Yang, M. G. Uberti, S Li, A. Schulick, H. Yu*  Statin and Stromal Cell Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels.  Stem Cells. 26（5）:1376-1384, 2008。

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