李晓明，男，1972年8月出生，医学博士，浙江大学医学院附属第二医院脑科中心主任，教授，博士生导师。并任浙江大学神经科学研究所所长，医学院党委书记，浙江大学副校长。早年毕业于原第一军医大学，获医学博士学位。历任浙江大学医学院副院长，附属第二医院副院长，医学院常务副院长等。

长期从事精神疾病的教学、科研和临床工作，聚焦于焦虑障碍、抑郁障碍等精神疾病的发病机制和临床转化研究，是国家基金委重大项目“焦虑障碍发病机制及临床转化研究”和国家科技创新2030重大项目“恐惧情绪的神经环路机制研究”的首席科学家，代表性论文发表在Cell, Nature Medicine, Nature Neuroscience，Neuron，Biological Psychiatry等国际一流学术期刊上，获得“抑郁症的诊断试剂盒”等多项发明专利。入选教育部“长江学者”特聘教授、中组部“万人计划”科技领军人才和科技部中青年科技领军人才，曾获得国家杰出青年基金、谈家桢生命科学创新奖、“吴杨”奖、中国神经科学学会-CST杰出神经科学家奖、中华医学科技一等奖等。

近5年代表性论文:

Representative papers in the last five years:

1.Hao Wang^#, Qin Wang^#, Liuze Cui^#, Xiaoyang Feng^#, Ping Dong, Liheng Tan, Lin Lin, Hong Lian, Shuxia Cao, Huiqian Huang, Peng Cao, Xiao-Ming Li*. A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.  Nature Neuroscience. 2024 In press

2.Yu-Ying Liao^#, Hui-Bing Zhang^#, Qing-Ya Shen^#, Chen-Xi Cai^#, Yu Ding, Dan-Dan Shen, Jia Guo, Jiao Qin, Ying-Jun Dong, Yan Zhang*, Xiao-Ming Li*. Snapshot of the cannabinoid receptor 1–arrestin unravels the biased signaling mechanism. Cell. 2023 Dec; 186(26): 5784-5797.

3.Yi Zhu^#, Shi-Ze Xie^#, Ai-Bing Peng^#, Xiao-Dan Yu, Chun-Yue Li, Jia-Yu Fu, Chen-Jie Shen, Shu-Xia Cao, Ying Zhang, Jia-Dong Chen, Xiao-Ming Li*. Distinct circuits from central lateral amygdala to ventral part of bed nucleus of stria terminalis regulate different fear memory. Biological Psychiatry. 2023 Sep 5:S0006-3223(23)01553-6.

4.Lin Zhu^#, Di Zheng^#, Rui Li, Chen-Jie Shen, Ruolan Cai, Chenfei Lyu, Binliang Tang, Hao Sun, Xiaohui Wang, Yu Ding, Bin Xu, Guoqiang Jia, Xinjian Li, Lixia Gao*, Xiao-Ming Li*. Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets. Neurosci Bulletin. 2023 Nov;39(11):1669-1682.

5.Bin Yu^#, Qianqian Zhang^#, Lin Lin^#, Xin Zhou, Wenji Ma, Shaonan Wen, Chunyue Li, Wei Wang, Qian Wu*, Xiaoqun Wang*, Xiao-Ming Li*. Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling. Cell Discovery. 2023 Feb 14;9(1):19. doi: 10.1038/s41421-022-00506-y.

6.Xiao-Dan Yu, Yi Zhu, Qi-Xin Sun, Fei Deng, Jin-Xia Wan, Di Zheng, Wan-Kun Gong, Shi-Ze Xie, Chen-Jie Shen, Jia-Yu Fu, Huiqian Huang, Hsin-Yi Lai, Jin Jin, Yu-Long Li, Xiao-Ming Li*. Diverse Serotonergic Pathways to the Amygdala Underlying Separable Behavioral Features of Anxiety. Nature Neuroscience. 2022, 12, 1651-1663.

7.Wang H^#, Dong P^#, He C^#, Feng XY^#, Huang Y, Yang WW, Gao HJ, Shen XF, Lin S, Cao SX, Lian H, Chen J, Yan M, Xiao-Ming Li*. Incerta-thalamic circuit controls pain threshold via cannabinoid type-1 receptors. Neuron. 2020, 107, 1–14.

8.Ying Zhang^#, Yi Zhu^#, Shu-Xia Cao, Peng Sun, Jian-Ming Yang, Yan-Fang Xia, Shi-Ze Xie, Xiao-Dan Yu, Jia-Yu Fu, Chen-Jie Shen, Hai-Yang He, Hao-Qi Pan, Xiao-Juan Chen, Hao Wang, Xiao-Ming Li*. MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning. Elife. 2020 May 18;9:e55342. doi: 10.7554/eLife.55342.

9.Jia-Yu Fu^#, Xiao-Dan Yu^#, Yi Zhu^#, Shi-Ze Xie, Meng-Yu Tang, Bin Yu, Xiao-Ming Li*. Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse. Neurosci Bulletin. 2020 Nov;36(11):1381-1394. doi: 10.1007/s12264-020-00545-z.

10.Chen-Jie Shen, Di Zheng, Ke-Xin Li, Yi Xie, Jia-Yu Fu, Xiao-Dan Yu, Hao-Qi Pan, Jia-Rui Li, Shumin Duan, Hailan Hu, Xiao-Ming Li*. Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive behavior. Nature Medicine(2019).

11.Ping Dong^#, Hao Wang^#, Xiao-Fan Shen, Ping Jiang, Xu-Tao Zhu, Yue Li, Jia-Hao Gao, Shan Lin, Yue Huang, Xiao-Bin He, Fu-Qiang Xu, Shu-Min Duan, Hong Lian, Hao Wang, Jia-Dong Chen, Xiao-Ming Li*. Thalamic reticular nucleus circuits for flight behavior. Nature Neuroscience (2019).

12.Yue Li^#, Chun-Yue Li^#, Wang Xi, Sen Jin, Zuo-Hang Wu, Ping Jiang, Ping Dong, Xiao-Bin He, Fu-Qiang Xu, Shu-Min Duan, Yu-Dong Zhou, Xiao-Ming Li*. Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence. Neuron(2019).