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基本信息:

姓名: 张进
职务: PI
职称: 研究员
学历: 博士
专业:
所属院系: 基础医学系
研究方向: 干细胞多能性维持的分子机制,基因调控网络与代谢网络相互作用对细胞命运的影响,iPS疾病模型的建立,以及干细胞分化免疫细胞的机制研究和临床转化。
电话:
信箱: zhgene@163.com
个人主页:

个人简介:

张进博士生导师。浙江大学医学院附属第一医院兼聘教授。


2005年毕业于浙江大学竺可桢学院。

2011年于加州大学洛杉矶分校取得博士学位。

2012-2017年于哈佛大学医学院/波士顿儿童医院从事多能干细胞的研究工作。

2016-2017年担任美国生物技术公司安进公司科学家,负责建立iPS新药靶点发现平台。


现主要研究方向为干细胞多能性维持的分子机制,基因调控网络与代谢网络相互作用对细胞命运的影响,iPS结合基因编辑进行疾病模型的建立,干细胞分化免疫细胞的机制研究和临床转化。


曾获得美国加州再生医学研究院的独立经费支持。在干细胞相关领域相关文章以第一作者或通讯作者身份发表于Cell Stem Cell, Cell Metabolism, Cell Report, EMBO Journal, Nature Protocol等杂志。多次在国际和国内学术会议上报告,包括2016年受邀为国际干细胞研究协会(ISSCR)年会报告人.


Publications


1.Yang L., Zhu Y., Yu H., Chen S., Chu Y., Huang H., Zhang J.*, Li, W.* Linking genotypes with multiple phenotypes in single-cell CRISPR screens June 03, 2019.bioRxiv


2.Zhu Y, Zhang J.* Calcium: A New Guardian of Naive Pluripotency. 2019 Aug 1;25(2):169-170. Cell Stem Cell.


3.Sun Z, Zhao J, Yu H, Zhang C, Li H, Zeng Z, Zhang J.*. Metabolomics in Stem Cell Biology Research.  2019; 1975:321-330. Methods in Molecular Biology.


4.Zhang Q, Li Z, Sun H, Zhang S, Zhang J, Wang Y, Fang H, Xu Y. Generation of induced pluripotent stem cell line (ZZUi0012-A) from a patient with Fahr's disease caused by a novel mutation in SLC20A2 gene.2019 Mar; 35:101395. Stem Cell Res.


5.Wang Y, Sun H, Yang J, Shi C, Liu Y, Xu Y, Zhang J. Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease.2019 Jan; 34:101366. Stem Cell Res.


6.Yanlin Wang, Zhilei Wang, Huifang Sun, Changhe Shi, Jing Yang, Yutao Liu, Han Liu, Shoutao Zhang, Li Zhang, Yuming Xu,  Zhang J.Generation of induced pluripotent stem cell line(ZZUi006-A)from a patient with myotonic dystrophy type 1. 2018 August. 22.Stem Cell Research


7.Wang Y, Jing N, Su L, Shi C, Zhang P, Wang Z, Sun H, Yang J, Liu Y, Wen X, Zhang J, Zhang S, Xu Y. Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation. 2018 Mar. 27:30-33, Stem Cell Research


8.Zhang, J.*,  Zhao, J., Dahan, P., Lu, V., Zhang, C., Hu, L., and  Teitell M.A.* Metabolism in Pluripotent Stem Cells and Early Mammalian Development. 2018 Feb. 27;2, p332-338, Cell Metabolism


9.Wang Z, Zhang P, Wang Y, Shi C, Jing N, Sun H, Yang J, Liu Y, Wen X, Zhang J, Zhang S, Xu Y. Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation. 2017 Dec;25:213-216, Stem Cell Research

 

10.Chandrasekaran, S*, Zhang, J.*,  Zhen Sun, Li Zhang, Ross, C.A., Huang, Y., Asara, J. M., Hu, L., Daley G.Q.,Collins, J.J.  Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. 2017 Dec. 5; 21, 10, p2965-2977, Cell Report

 

11.Zhang, J.*, Nioi, P., Hu, L., Tounsen, A., Wu, C. J. Combining hiPSCs and Human Genetics: Major Applications in Drug Development. 2017 Aug. 3; 21,2, p161-165, Cell Stem Cell

 

12.Zhang, J.*, Ratanasirintrawoot, S.*, Chandrasekaran, S, Wu, Z., Ficarro, S.B., Yu, C., Cacchiarelli, D., Ross, C.A., Xia, Q., Seligson,M, Shinoda, G., Xie, W., Cahan, P., Wang, L., Shyh-Chang, N., Tintara, S., Trapnell, C., Onder, T., Loh, Y., Asara, J.M., Mikkelsen, T., Teitell, M., Sliz P., Marto, J.M., Hu, L., Collins, J.J., Daley, G. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. 2016 July 7; 19, 1-15, Cell Stem Cell


13.Xie, Y., Zhang, J., Lin, Y., Meng, X., Wisidagama, D.R.R., Cinkornpumin, Koehler, C.M., Malone, C.S., Teitell, M.A., and Lowry, W.E. Defining Role of Oxygen Tension in Human Neural Cell Fate. 2014 Nov 11; 3(5): 743–757, Stem Cell Reports, 2014

 

14.Kumar, K., Cahan, P., Shalek, A., Satija, R., Li, H, Zhang, J., Pardee, K., Gennert, D., Trombetta, J., Ferrante, T., Regev, A., Collins, J., Daley, G. Deconstructing transcriptional heterogeneity in pluripotent stem cells. 2014 Dec 4; 516(7529): 56-61, Nature, 2014

 

15.Urbach, A., Yermalovich, A., Zhang, J., et. al. Daley, G. Lin28 sustains early renal progenitors and induces Wilms tumor Gene & Development, 2014, 28(9):971-82

 

16.Zangle, T.A., Chun, J., Zhang, J., Reed, J., Teitell, M. Quantification of Biomass and Cell Motion in Human Pluripotent Stem Cell Colonies, Biophysical Journal, 2013, 105(3): 593-601


17.Cherry A.B., Gagne K.E., McLoughlin E.M., Baccei A, Gorman B, Hartung O, Miller J.D., Zhang J, Zon R.L., Ince T.A., Neufeld E.J., Lerou P.H., Fleming M.D., Daley G.Q., Agarwal S., Induced pluripotent stem cells with a mitochondrial DNA deletion, Stem Cells, 2013, 31(7): 1287-97

 

18.Shyh-Chang N, Locasale J.W., Lyssiotis C.A., Zheng Y., Teo R.Y., Ratanasirintrawoot S., Zhang J., Onder T., Unternaehrer J.J., Zhu H., Asara J.M., Daley G.Q., Cantley L.C. Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation. Science, 2012, 339(6116):222-6


19.Wang, G., Shimada, E., Zhang, J., Hong, J.S., Smith, M.G., Teitell, M.A., Koehler, C.M. Correcting Mitochondrial Mutations with Targeted RNA Import, PNAS, 2012, 109 (13): 4840-5


20.Zhang, J., Neuble, E., Daley, G.Q., Koehler, C.M., Teitell. M.A. Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-renewal, Cell Stem Cell, 2012, 11(5): 589-95


21.Zhang, J. Neuble, E., Wisidagama, R., Malone, C., Teitell, M.A. Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells, Nature Protocols, 2012 7(6): 1068-85


22.Zhang, J., Hong, J.S., Vergnes L., Reue, K., Koehler, C.M., and Teitell, M.A. UCP2 Regulates Energy Metabolism in Human Pluripotent Stem Cells, EMBO Journal, 2011, 30(24):4860-73


23.Wahjudi, P.N., Yee, Y., Martinez, S.R., Zhang, J., Teitell, M.A., Nikolaenko, L., Swerdloff, R, Christina, W., Lee, W.N.P. Turnover of non-essential fatty acids in cardiolipin from the rat heart, Journal of Lipid Research, 2011, 52(12): 2226-33


24.Wang, G., Chen, H., Oktay, Y., Zhang, J., Allen, E.L., Smith, G.M., Fan, K.C., Hong, J.S., French, S.W., McCaffery, J.M, Lightowlers, R.N., Morse III, H.C., Koehler, C.M., and Teitell, M.A. PNPASE Regulates RNA Import into Mitochondria. Cell, 2010 142;3: 456-467 


25.Chin, M., Mason, M., Xie, W., Volinia, S., Singer, M., Peterson, C., Clark, A., Richter, L., Aimuwu, O.,Zhang, J., Khvorostov, I., Ott, V., Grunstein, M., Benvenisty, N., Croce, C., Clark, A., Baxter, T., Pyle, A., Teitell, M., Pellegrini, M., Plath, K., and Lowry, W. Induced Pluripotent Stem Cells and Embryonic Stem Cells are Distinguished by Gene Expression Signatures. Cell Stem Cell, 2009 2;5(1):111-23 


26.Zhang, J., Khvorostov, I.B., and Teitell, M.A. From MEFs to Matrigel 1: Passaging hESCs in the Presence of MEFs. Journal of Visualized Experiments, 2008  


27.Khvorostov, I.B., Zhang, J., and Teitell, M.A. Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells. Journal of Visualized Experiments, 2008